Genotyping assay performance | Time | Designated composite prevalence (SD) | LA only | Sequential testing | ||
---|---|---|---|---|---|---|
Composite prevalence estimate (SD) | Estimate-to-true ratio | Composite prevalence estimate (SD) | Estimate-to-true ratio | |||
United States | ||||||
Sen = 1.00 Spe = 1.00 | Baseline | 0.047 (0.003) | 0.047 (0.003) | 1.000 | 0.009 (0.002) | 0.191 |
Reduced | 0.023 (0.002) | 0.023 (0.002) | 1.000 | 0.004 (0.001) | 0.173 | |
% Reduction | 51.1 | 51.1 | 50 | |||
Sen = 0.95 Spe = 0.95 | Baseline | 0.047 (0.003) | 0.092 (0.004) | 1.958 | 0.028 (0.003) | 0.596 |
Reduced | 0.023 (0.002) | 0.071 (0.004) | 3.087 | 0.021 (0.002) | 0.913 | |
% Reduction | 51.1 | 22.8 | 0.7 | |||
Sen = 0.95 Spe = 0.90 | Baseline | 0.047 (0.003) | 0.140 (0.006) | 2.979 | 0.052 (0.004) | 1.106 |
Reduced | 0.023 (0.002) | 0.120 (0.005) | 5.217 | 0.044 (0.003) | 1.913 | |
% Reduction | 51.1 | 14.3 | 15.4 | |||
Sen = 0.90 Spe = 0.90 | Baseline | 0.047 (0.003) | 0.138 (0.005) | 2.936 | 0.051 (0.003) | 1.085 |
Reduced | 0.023 (0.002) | 0.119 (0.005) | 5.174 | 0.044 (0.003) | 1.913 | |
% Reduction | 51.1 | 13.8 | 13.7 | |||
Sen = 0.90 Spe = 0.85 | Baseline | 0.047 (0.003) | 0.185 (0.006) | 3.936 | 0.075 (0.004) | 1.596 |
Reduced | 0.023 (0.002) | 0.167 (0.007) | 7.261 | 0.068 (0.004) | 2.957 | |
% Reduction | 51.1 | 9.7 | 9.3 | |||
Sen = 0.85 Spe = 0.85 | Baseline | 0.047 (0.003) | 0.183 (0.006) | 3.894 | 0.074 (0.004) | 1.574 |
Reduced | 0.023 (0.002) | 0.166 (0.006) | 7.217 | 0.068 (0.004) | 2.957 | |
% Reduction | 51.1 | 9.3 | 8.1 | |||
Sen = 0.80 Spe = 0.80 | Baseline | 0.047 (0.003) | 0.228 (0.006) | 4.851 | 0.097 (0.005) | 2.064 |
Reduced | 0.024 (0.002) | 0.214 (0.006) | 8.917 | 0.091 (0.005) | 3.792 | |
% Reduction | 51.1 | 6.1 | 6.2 | |||
Latin America | ||||||
Sen = 1.00 Spe = 1.00 | Baseline | 0.033 (0.003) | 0.033 (0.003) | 1.000 | 0.004 (0.001) | 0.125 |
Reduced | 0.016 (0.002) | 0.016 (0.002) | 1.000 | 0.002 (0.001) | 0.125 | |
% Reduction | 51.5 | 51.5 | 50 | |||
Sen = 0.95 Spe = 0.95 | Baseline | 0.033 (0.003) | 0.080 (0.004) | 2.424 | 0.022 (0.002) | 0.667 |
Reduced | 0.016 (0.002) | 0.065 (0.004) | 4.063 | 0.017 (0.002) | 1.063 | |
% Reduction | 51.5 | 18.7 | 22.7 | |||
Sen = 0.95 Spe = 0.90 | Baseline | 0.033 (0.003) | 0.128 (0.005) | 3.879 | 0.046 (0.003) | 1.394 |
Reduced | 0.016 (0.002) | 0.114 (0.005) | 7.125 | 0.040 (0.003) | 2.500 | |
% Reduction | 51.5 | 10.9 | 13.0 | |||
Sen = 0.90 Spe = 0.90 | Baseline | 0.033 (0.003) | 0.126 (0.005) | 3.818 | 0.045 (0.003) | 1.364 |
Reduced | 0.016 (0.002) | 0.113 (0.005) | 7.063 | 0.040 (0.003) | 2.500 | |
% Reduction | 51.5 | 10.3 | 11.1 | |||
Sen = 0.90 Spe = 0.85 | Baseline | 0.033 (0.003) | 0.175 (0.006) | 5.303 | 0.070 (0.004) | 2.121 |
Reduced | 0.016 (0.002) | 0.162 (0.006) | 10.125 | 0.065 (0.004) | 4.063 | |
% Reduction | 51.5 | 7.4 | 7.1 | |||
Sen = 0.85 Spe = 0.85 | Baseline | 0.033 (0.003) | 0.173 (0.006) | 5.242 | 0.069 (0.004) | 2.091 |
Reduced | 0.016 (0.002) | 0.161 (0.005) | 10.062 | 0.064 (0.004) | 4.000 | |
% Reduction | 51.5 | 6.9 | 7.2 | |||
Sen = 0.80 Spe = 0.80 | Baseline | 0.033 (0.003) | 0.219 (0.006) | 6.636 | 0.093 (0.005) | 2.818 |
Reduced | 0.016 (0.002) | 0.209 (0.006) | 13.064 | 0.089 (0.004) | 5.563 | |
% Reduction | 51.5 | 4.5 | 4.3 |