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Table 2 Incidence rate per 1000 person years, unadjusted and adjusted hazard ratios of association between patient and clinical factors with virological failure

From: Virological failure reduced with HIV-serostatus disclosure, extra baseline weight and rising CD4 cells among HIV-positive adults in Northwestern Uganda

Variable

Total No. = 383

Plasma Viral load (>5, 000 copies/uL) No. = 28

Incidence rate per 1000 person-years

uHR (95 % CI)

P-value

aHR (95 % CI) Adjusted for all variables with P < 5 % at unadjusted level & WHO clinical stage

P-value

Age in years

 Below 30

169 (44.1)

12

57.2 (32.5-100.7)

1

   

 Above 30

214 (55.9)

16

58.7 (35.9-95.7)

0.98 (0.46-2.08)

0.947

  

Residence

 Rural

294 (76.8)

25

67.3 (45.5-99.7)

1

   

 Urban

89 (23.2)

3

26.9 (8.7-83.5)

0.40 (0.12-1.33)

0.134

  

Marital status

 Single

54 (14.1)

6

103.2 (46.4-229.8)

1

   

 Married

234 (61.1)

15

50.6 (30.5-83.8)

0.36 (0.14-0.95)

0.05

  

 Separated

71 (18.5)

6

62.8 (28.2-139.8)

0.43 (0.13-1.35)

0.148

  

 One partner is dead

24 (6.3)

1

31.0 (4.4-219.8)

0.20 (0.02-1.67)

0.136

  

Occupation

 Formal employment

79 (20.6)

7

72.1 (34.4-151.3)

1

   

 Self-employment

167 (43.6)

11

52.0 (28.8-93.9)

0.64 (0.25-1.67)

0.362

  

 Not employed

137 (35.8)

10

57.4 (30.9-106.8)

0.73 (0.28-1.91)

0.519

  

Educational level

 None

41 (10.7)

4

76.1 (28.6-202.8)

1

   

 Primary

95 (24.8)

4

32.3 (12.1-86.0)

0.40 (0.10-1.61)

0.199

  

 Secondary

154 (40.2)

12

63.1 (35.9-111.2)

0.86 (0.28-2.67)

0.795

  

 Tertiary

93 (24.3)

8

68.9 (34.5-137.8)

0.96 (0.29-3.19)

0.946

  

Religion

 Catholic

203 (53.0)

14

53.9 (31.9-91.0)

1

   

 Moslem

46 (12.0)

2

38.4 (9.6-153.4)

0.78 (0.18-3.46)

0.749

  

 Anglican

134 (35.0)

12

70.3 (39.9-123.7)

1.28 (0.59-2.77)

0.529

  

Tribe

 Lugbara

290 (75.7)

17

47.3 (29.4-76.1)

1

1

  

 Ma’ di

14 (3.7)

1

57.7 (8.1-409.8)

1.20 (0.16-9.04)

0.860

  

 Luo

79 (20.6)

10

94.2 (50.7-175.2)

1.82 (0.83-3.94)

0.134

  

Sex

 Male

145 (37.9)

14 (9.7)

82.0 (48.2-138.4)

1

 

1

 

 Female

238 (62.1)

14 (5.9)

44.9 (26.6-75.8)

0.45 (0.21-0.95)

0.035

0.45 (0.19-1.03)

0.059

Baseline WHO staging

   

1

 

1

 

 I/II

359 (93.7)

21 (5.8)

59.6 (40.9-86.9)

0.60 (0.08-4.40)

0.612

0.60 (0.08-4.80)

0.632

 III/IV

24 (6.3)

7 (29.2)

33.9 (4.8-240.4)

    

Baseline weight/Kgs

 Less or equals 56 Kgs

194 (50.7)

20 (10.3)

82.0 (52.9-127.1)

1

 

1

 

 More than 56 Kgs

189 (49.4)

8 (4.2)

33.5 (16.8-67.0)

0.39 (0.17-0.89)

0.025

1.14 (0.31-4.14)

0.845

 1-kg increase

   

0.92 (0.86-0.98)

0.008

0.86 (0.76-0.96)

0.008

Baseline CD4 cells/uL

 Less or equals 250 cells/uL

192 (50.1)

21 (10.9)

92.3 (60.2-141.6)

1

 

1

 

 More than 250 cells/uL

191 (49.9)

7 (3.7)

27.4 (13.1-57.6)

0.26 (0.11-0.61)

0.002

0.32 (0.08-1.20)

0.091

 1-CD4 cell increase

   

0.99 (0.99-0.10)

0.005

1.01 (1.00-1.01)

0.133

Recent CD4 cells/uL

 Less or equals 362 cells/uL

194 (50.7)

21 (10.8)

84.9 (55.3-130.1)

1

 

1

 

 More than 362 cells/uL

189 (49.3)

7 (3.7)

29.8 (14.2-62.4)

0.36 (0.15-0.85)

0.021

5.02 (1.11-22.72)

0.056

 1-CD4 cell increase/uL

   

0.99 (0.99-1.00)

<0.001

0.99 (0.98-0.99)

<0.001

HIV sero-status disclosure

 No

68 (17.8)

14 (20.6)

177.9 (105.4-300.4)

1

 

1

 

 Yes

315 (82.3)

14 (44.4)

34.7 (20.5-58.5)

0.18 (0.08-0.37)

<0.001

0.15 (0.06-0.33)

<0.001

  1. Note
  2. -Percentages calculated as row percentages (n/N)
  3. -Level of significance was 5 %
  4. -Bolded P-values are significant at 5 %
  5. -uHR Unadjusted Hazard Ratio, aHR Adjusted Hazard Ratio, CI Confidence interval, WHO World Health Organization, CD4 Cluster of Cell Differentiation-4