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Table 3 Diagnostic performance* of the Leucocyte Esterase Test (LET) after a reading time of 2 min (“LET 2 m”) and 5 min (“LET 5 m”) in the detection of urogenital Chlamydia Trachomatis (Ct) among male patients, STI outpatient clinic, Amsterdam, The Netherlands, 2009–2010

From: Leucocyte esterase dip-stick test as a point-of-care diagnostic for urogenital chlamydia in male patients: A multi-center evaluation in two STI outpatient clinics in Paramaribo and Amsterdam

  N LET+ NAAT+ LET- NAAT+ LET+ NAAT- LET- NAAT- Sens. (95 % CI) Spec. (95 % CI) PPV (95 % CI) NPV (95 % CI) Agr. Kappa
LET 2 m
 ALL 645 68 20 233 324 77.3 % (67.1–85.5) 58.1 % (53.9–62.3) 22.6 % (18.0–27.7) 94.2 % (91.1–96.4) 60.8 % 0.176
 Sympto-matic patients 257 44 9 100 104 83.0 % (70.2–91.9) 51.0 % (43.9–58.0) 30.6 % (23.2–38.8) 92.0 % (85.4–96.3) 57.6 % 0.208
 Asympto-matic patients 379 23 11 129 216 67.6 % (49.5–82.6) 62.6 % (57.2–67.7) 15.1 % (9.8–21.8) 95.1 % (91.4–97.5) 63.1 % 0.026
 <25 years 110 18 3 41 48 85.7 % (63.7–97.0) 53.9 % (43.0–64.6) 30.5 % (19.2–43.9) 94.1 % (84.8–98.8) 60.0 % 0.068
LET 5 m
 ALL 645 80 8 330 227 90.9 % (82.9–96.0) 40.8 % (36.7–45.0) 19.6 % (15.9–23.8) 96.6 % (93.4–98.5) 47.6 % 0.125
  1. *Sensitivity (Sens.), Specificity (Spec.), Positive Predictive Value (PPV), Negative Predictive Value (NPV), Agreement (Agr.) and Kappa