Table 3 Characteristics associated with epidemiologic links being identified by CLI TB patient interviews (Step 4) versus earlier in CLI (Steps 1–3)
Epi-linked patient-pairs with concordant PCRTypes | Unadjusted | Adjusteda | ||||||
|---|---|---|---|---|---|---|---|---|
Identified without CLI TB patient interviews (n = 158) | Identified by CLI TB patient interviews (n = 30) | OR | p-value | 95 % CI | OR | p-value | 95 % CI | |
Study site, n (%) | ||||||||
Texas (City of Houston) | 45 (28.5 %) | 15 (50.0 %) | 2.51 | 0.226 | 0.57, 11.16 | 0.20 | 0.191 | 0.02, 2.25 |
Massachusetts | 26 (16.5 %) | 2 (6.7 %) | 0.36 | 0.218 | 0.07, 1.82 | 0.04 | 0.004 | 0.00, 0.35 |
Maryland | 48 (30.4 %) | 1 (3.3 %) | 0.08 | 0.050 | 0.01, 1.00 | 0.01 | 0.036 | 0.00, 0.73 |
Georgia | 39 (24.7 %) | 12 (40.0 %) | 2.03 | 0.357 | 0.45, 9.22 | -- | ||
Race/ethnicity, n (%) | ||||||||
Asian | 4 (2.5 %) | 5 (16.7 %) | 7.70 | <0.001 | 3.12, 19.00 | 0.28 | 0.349 | 0.02, 4.07 |
Black | 93 (58.9 %) | 6 (20.0 %) | 0.18 | 0.010 | 0.05, 0.66 | 0.21 | 0.036 | 0.05, 0.90 |
Hispanic | 32 (20.1 %) | 13 (43.3 %) | 3.01 | 0.211 | 0.53, 16.97 | -- | ||
White | 24 (10.8 %) | 6 (10.0 %) | 1.11 | 0.889 | 0.25, 4.94 | -- | ||
Transmission setting, n (%) | ||||||||
Household | 29 (18.4 %) | 0 (0.0 %) | NA | -- | ||||
Close social | 27 (17.1 %) | 2 (6.7 %) | 0.35 | 0.147 | 0.08, 1.45 | -- | ||
Workplace | 5 (3.2 %) | 4 (13.3 %) | 4.71 | 0.015 | 1.36, 16.35 | 7.16 | 0.032 | 1.19, 43.08 |
Shelter | 58 (36.7 %) | 4 (13.3 %) | 0.27 | 0.139 | 0.05, 1.54 | -- | ||
Church | 5 (3.2 %) | 8 (26.7 %) | 11.13 | 0.051 | 0.99, 125.43 | 10.98 | 0.046 | 1.04, 116.08 |
Drug house | 17 (10.8 %) | 2 (6.7 %) | 0.59 | 0.579 | 0.09, 3.76 | -- | ||
Other | 17 (10.8 %) | 10 (33.3 %) | 0.24 | 0.047 | 0.06, 0.98 | 0.25 | 0.024 | 0.08, 0.83 |
Relationship between case pairs, n (%) | ||||||||
Relative | 25 (15.8 %) | 0 (0.0 %) | NA | -- | ||||
Friend | 41 (26.0 %) | 4 (13.3 %) | 0.44 | 0.204 | 0.12, 1.56 | -- | ||
Coworker | 4 (2.5 %) | 4 (13.3 %) | 5.92 | 0.008 | 1.58, 22.27 | -- | ||
Genotype lineage, n (%) | ||||||||
East Asian (L2) lineage | 30 (19.0 %) | 12 (40.0 %) | 2.84 | 0.118 | 0.77, 10.54 | 0.98 | 0.976 | 0.19, 5.07 |
Euro-American (L4) lineage | 122 (77.2 %) | 18 (60.0 %) | 0.44 | 0.229 | 0.12, 1.67 | -- | ||
Common genotype in US†, n (%) | 8 (5.1 %) | 2 (6.7 %) | 1.34 | 0.709 | 0.29, 6.21 | -- | ||
Extra-pulmonary only site of TB, n (%) | 8 (5.1 %) | 6 (20.0 %) | 4.69 | 0.033 | 1.13, 19.42 | 9.54 | 0.105 | 0.62, 146.32 |
US-birth, n (%) | 132 (83.5 %) | 24 (80.0 %) | 0.79 | 0.739 | 0.19, 3.21 | -- | ||
HIV infection, n (%) | 54 (34.2 %) | 6 (20.0 %) | 0.48 | 0.301 | 0.12, 1.92 | -- | ||
Incarcerated at TB diagnosis, n (%) | 10 (6.3 %) | 1 (3.3 %) | 0.51 | 0.567 | 0.05, 5.10 | -- | ||
Homeless, n (%) | 83 (52.5 %) | 8 (26.7 %) | 0.33 | 0.136 | 0.08, 1.42 | -- | ||
Excess alcohol use, n (%) | 112 (70.9 %) | 15 (50.0 %) | 0.41 | 0.146 | 0.12, 1.37 | -- | ||
Non-injection drug use, n (%) | 70 (44.3 %) | 8 (26.7 %) | 0.46 | 0.058 | 0.20, 1.03 | 0.48 | 0.118 | 0.19, 1.21 |
Patient pairs with different zip codes in same jurisdiction, n (%) | 99 (66.9 %) | 22 (88.0 %) | 3.63 | 0.022 | 1.21, 10.89 | 2.84 | 0.174 | 0.63, 12.83 |
Patient pairs from different jurisdictions, n (%) | 10 (6.3 %) | 5 (16.7 %) | 2.96 | 0.103 | 0.81, 10.89 | 4.41 | 0.070 | 0.89, 21.95 |
Epidemiologic link strength = “definite”, n (%) | 114 (72.2 %) | 10 (33.3 %) | 0.19 | <0.001 | 0.08, 0.45 | 0.22 | 0.007 | 0.22, 43.23 |