|
Total n (%)
|
cTB status n (%)
|
Unadjasted p-value
|
#Adjusted p-value
|
---|
|
Definite-TB
|
Unconfirmed-TB
|
Unlikely-TB
| | |
---|
Number of participants
|
214 (100)
|
34 (16)
|
86 (40)
|
94 (44)
| | |
Bacteria
|
M. catarrhalis
|
137 (64)
|
24 (71)
|
56 (65)
|
57 (60)
|
0.64
|
1.00
|
S. pneumoniae
|
90 (42)
|
18 (53)
|
38 (44)
|
34 (36)
|
0.22
|
1.00
|
H. influenzae spp
|
62 (29)
|
8 (24)
|
25 (29)
|
29 (31)
|
0.44
|
1.00
|
S. aureus
|
47 (22)
|
7 (21)
|
18 (21)
|
22 (23)
|
0.79
|
1.00
|
H. influenzae B
|
31 (15)
|
5 (15)
|
15 (17)
|
11 (12)
|
0.97
|
1.00
|
M. pneumoniae
|
19 (9)
|
2 (6)
|
9 (10)
|
8 (9)
|
0.84
|
1.00
|
B. pertussis
|
12 (6)
|
3 (9)
|
6 (7)
|
3 (3)
|
0.43
|
1.00
|
C. pneumoniae
|
9 (4)
|
4 (12)
|
4 (5)
|
1 (1)
|
0.03
|
0.42
|
Viruses
|
Metapneumovirus A/B
|
41 (19)
|
7 (21)
|
21 (24)
|
13 (14)
|
0.60
|
1.00
|
Rhinovirus
|
31 (15)
|
6 (18)
|
13 (15)
|
12 (13)
|
0.77
|
1.00
|
Enterovirus
|
22 (10)
|
1 (3)
|
10 (12)
|
11 (12)
|
0.21
|
1.00
|
Adenovirus
|
14 (7)
|
3 (9)
|
5 (6)
|
6 (6)
|
0.99
|
1.00
|
Cytomegalovirus
|
14 (7)
|
3 (9)
|
3 (3)
|
8 (9)
|
1.00
|
1.00
|
Bocavirus
|
14 (7)
|
8 (24)
|
1 (1)
|
5 (5)
|
1.00
|
1.00
|
Coronavirus
|
17 (8)
|
5 (15)
|
8 (9)
|
4 (4)
|
0.13
|
0.94
|
Coronavirus O43
|
12 (6)
|
5 (15)
|
5 (6)
|
2 (2)
|
0.02
|
0.42
|
Coronavirus HKU
|
2 (1)
|
0 (0)
|
1 (1)
|
1 (1)
|
1.00
|
1.00
|
Coronavirus NL63
|
2 (1)
|
0 (0)
|
1 (1)
|
1 (1)
|
1.00
|
1.00
|
Coronavirus 229E
|
1 (0.5)
|
0 (0)
|
1 (1)
|
0 (0)
|
nad
|
nad
|
RSV A/Bb
|
7 (3)
|
1 (3)
|
3 (3)
|
3 (3)
|
1.00
|
1.00
|
Influenza virus
|
33 (15)
|
8 (24)
|
15 (17)
|
10 (11)
|
0.17
|
0.94
|
Influenza A
|
7 (3)
|
1 (3)
|
4 (5)
|
2 (2)
|
1.00
|
1.00
|
Influenza B
|
7 (3)
|
1 (3)
|
2 (2)
|
4 (4)
|
1.00
|
1.00
|
Influenza C
|
19 (9)
|
6 (18)
|
9 (10)
|
4 (4)
|
0.04
|
0.43
|
Parainfluenza virus
|
10 (5)
|
1 (3)
|
4 (5)
|
5 (5)
|
0.88
|
1.00
|
Parainfluenza 1
|
5 (2)
|
1 (3)
|
2 (2)
|
2 (2)
|
1.00
|
1.00
|
Parainfluenza 2
|
1 (0.5)
|
0 (0)
|
0 (0)
|
1 (1)
|
1.00
|
1.00
|
Parainfluenza 3
|
2 (1)
|
0 (0)
|
1 (1)
|
1 (1)
|
1.00
|
1.00
|
Parainfluenza 4
|
2 (1)
|
0 (0)
|
1 (1)
|
1 (1)
|
1.00
|
1.00
|
Both Bacteria & Viruses
|
124 (58)
|
24 (73)
|
48 (56)
|
52 (55)
|
-
|
0.11
|
Fungi
|
P. jirovecii
|
23 (11)
|
3 (9)
|
10 (12)
|
10 (11)
|
0.94
|
1.00
|
- aArranged in order of decreasing colonisation or detection rates
- bRSV A/B = Respiratory Syncyntial virus A and B
- #The adjusted p-value compensates for multiple comparisons. The p-values only compare the presence of each microbe between the definite-TB and unlikely-TB groups. The true proportion of TB in the unconfirmed-TB is unknown hence not included in comparison
- cTB = Microbiological confirmation of pulmonary Tuberculosis
- nad = Non of the children had Coronavirus 229 present, except in the unconfirmed-TB category which is excluded