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Table 2 Respiratory microbes detected from children presenting with suspected pulmonary tuberculosisa

From: Respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in Cape Town, South Africa

 

Total n (%)

cTB status n (%)

Unadjasted p-value

#Adjusted p-value

 

Definite-TB

Unconfirmed-TB

Unlikely-TB

  

Number of participants

214 (100)

34 (16)

86 (40)

94 (44)

  

Bacteria

 M. catarrhalis

137 (64)

24 (71)

56 (65)

57 (60)

0.64

1.00

 S. pneumoniae

90 (42)

18 (53)

38 (44)

34 (36)

0.22

1.00

 H. influenzae spp

62 (29)

8 (24)

25 (29)

29 (31)

0.44

1.00

 S. aureus

47 (22)

7 (21)

18 (21)

22 (23)

0.79

1.00

 H. influenzae B

31 (15)

5 (15)

15 (17)

11 (12)

0.97

1.00

 M. pneumoniae

19 (9)

2 (6)

9 (10)

8 (9)

0.84

1.00

 B. pertussis

12 (6)

3 (9)

6 (7)

3 (3)

0.43

1.00

 C. pneumoniae

9 (4)

4 (12)

4 (5)

1 (1)

0.03

0.42

Viruses

 Metapneumovirus A/B

41 (19)

7 (21)

21 (24)

13 (14)

0.60

1.00

 Rhinovirus

31 (15)

6 (18)

13 (15)

12 (13)

0.77

1.00

 Enterovirus

22 (10)

1 (3)

10 (12)

11 (12)

0.21

1.00

 Adenovirus

14 (7)

3 (9)

5 (6)

6 (6)

0.99

1.00

 Cytomegalovirus

14 (7)

3 (9)

3 (3)

8 (9)

1.00

1.00

 Bocavirus

14 (7)

8 (24)

1 (1)

5 (5)

1.00

1.00

 Coronavirus

17 (8)

5 (15)

8 (9)

4 (4)

0.13

0.94

  Coronavirus O43

12 (6)

5 (15)

5 (6)

2 (2)

0.02

0.42

  Coronavirus HKU

2 (1)

0 (0)

1 (1)

1 (1)

1.00

1.00

  Coronavirus NL63

2 (1)

0 (0)

1 (1)

1 (1)

1.00

1.00

  Coronavirus 229E

1 (0.5)

0 (0)

1 (1)

0 (0)

nad

nad

 RSV A/Bb

7 (3)

1 (3)

3 (3)

3 (3)

1.00

1.00

 Influenza virus

33 (15)

8 (24)

15 (17)

10 (11)

0.17

0.94

  Influenza A

7 (3)

1 (3)

4 (5)

2 (2)

1.00

1.00

  Influenza B

7 (3)

1 (3)

2 (2)

4 (4)

1.00

1.00

  Influenza C

19 (9)

6 (18)

9 (10)

4 (4)

0.04

0.43

 Parainfluenza virus

10 (5)

1 (3)

4 (5)

5 (5)

0.88

1.00

  Parainfluenza 1

5 (2)

1 (3)

2 (2)

2 (2)

1.00

1.00

  Parainfluenza 2

1 (0.5)

0 (0)

0 (0)

1 (1)

1.00

1.00

  Parainfluenza 3

2 (1)

0 (0)

1 (1)

1 (1)

1.00

1.00

  Parainfluenza 4

2 (1)

0 (0)

1 (1)

1 (1)

1.00

1.00

 Both Bacteria & Viruses

124 (58)

24 (73)

48 (56)

52 (55)

-

0.11

Fungi

 P. jirovecii

23 (11)

3 (9)

10 (12)

10 (11)

0.94

1.00

  1. aArranged in order of decreasing colonisation or detection rates
  2. bRSV A/B = Respiratory Syncyntial virus A and B
  3. #The adjusted p-value compensates for multiple comparisons. The p-values only compare the presence of each microbe between the definite-TB and unlikely-TB groups. The true proportion of TB in the unconfirmed-TB is unknown hence not included in comparison
  4. cTB = Microbiological confirmation of pulmonary Tuberculosis
  5. nad = Non of the children had Coronavirus 229 present, except in the unconfirmed-TB category which is excluded