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Table 1 Characteristics of patients at initiation of second-line TB treatment (n = 578)

From: Severe adverse events during second-line tuberculosis treatment in the context of high HIV Co-infection in South Africa: a retrospective cohort study

Characteristic

Description

Count

Proportion

Sex

Male

283

49.0 %

Female

295

51.0 %

Age

10–24 years

56

9.7 %

25–39 years

338

58.5 %

40–54 years

163

28.2 %

55+ years

21

3.6 %

Weight (kg)

Low weight (≤50 kg)

195

36.7 %

>51 kg

337

63.3 %

Missing

46

8.0 %

TB foci

Pulmonary

541

93.6 %

Extrapulmonary only

37

6.4 %

Prior TB

No history of TB treatment

439

76.0 %

Prior first-line TB treatment

119

20.6 %

Prior TB treatment with streptomycin

7

1.2 %

Unknown

13

2.2 %

Current TB diagnosis

MDR-TB (INH and RIF resistance)

182

31.5 %

RIF mono-resistant TB

198

34.3 %

RIF resistant, sensitivities unknown

191

33.0 %

XDR TB (second-line resistance)

7

1.2 %

Presenting symptoms

Cough

281

65.9 %

Any of cough, weight loss, fever, night sweats

453

78.4 %

Sputum smear microscopy

Positive (scanty or higher)

284

49.1 %

Negative or unknown

294

50.9 %

Level of care at TB diagnosis

Outpatient, ambulatory

406

70.2 %

Inpatient, hospitalized

155

26.8 %

Missing

17

2.9 %

  1. MDR-TB multi-drug resistant tuberculosis, RIF rifampicin, INH isoniazid, XDR TB extensively drug-resistant tuberculosis