Predictors of viral suppression and rebound among HIV-positive men who have sex with men in a large multi-site Canadian cohort

Table 3 Accelerated failure time models of factors associated with time to viral suppression among MSM

	Unadjusted hazard ratio (95 % confidence interval)	P-value	Adjusted hazard ratio (95 % confidence interval)	P-value
Province
British Columbia	1.00	0.004	1.00	0.126
Ontario	1.04 (0.93–1.15)		0.98 (0.88–1.10)
Quebec	1.19 (1.07–1.32)		1.09 (0.98–1.22)
Baseline age (per 10 year increment)	1.06 (1.02–1.11)	0.007	1.08 (1.03–1.13)	0.001
Ethnicity
Caucasian	1.00	0.001
Black	0.97 (0.68–1.39)
Aboriginal	0.75 (0.55–1.01)
Other	1.23 (1.07–1.40)
Unknown	1.13 (1.03–1.25)
History of IDU
No	1.00	<0.001	1.00	<0.001
Yes	0.70 (0.60–0.83)		0.71 (0.60–0.85)
Unknown	0.63 (0.44–0.89)		0.71 (0.50–1.02)
Era of cART initiation
2000–03	1.00	<0.001	1.00	<0.001
2004–07	1.24 (1.11–1.39)		1.26 (1.11–1.42)
2008–12	1.42 (1.27–1.58)		1.32 (1.17–1.48)
Initial 3rd ARV class
NNRTI	1.00	<0.001	1.00	<0.001
Unboosted PI	0.53 (0.42–0.67)		0.60 (0.48–0.76)
Boosted PI	0.82 (0.75–0.90)		0.81 (0.74–0.90)
Other	0.81 (0.67–0.97)		0.83 (0.69–1.00)
Baseline AIDS-defining illness
No	1.00	0.011
Yes	0.84 (0.74–0.94)
Unknown	1.04 (0.84–1.29)
Baseline viral load (per log10 copies/mL)	0.73 (0.66–0.80)	<0.001	0.73 (0.66–0.80)	<0.001
Baseline CD4 count (per 100 cells/mm³)	1.04 (1.02–1.07)	<0.001

ISSN: 1471-2334