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Table 3 Accelerated failure time models of factors associated with time to viral suppression among MSM

From: Predictors of viral suppression and rebound among HIV-positive men who have sex with men in a large multi-site Canadian cohort

 

Unadjusted hazard ratio

(95 % confidence interval)

P-value

Adjusted hazard ratio (95 % confidence interval)

P-value

Province

 British Columbia

1.00

0.004

1.00

0.126

 Ontario

1.04 (0.93–1.15)

0.98 (0.88–1.10)

 Quebec

1.19 (1.07–1.32)

1.09 (0.98–1.22)

Baseline age (per 10 year increment)

1.06 (1.02–1.11)

0.007

1.08 (1.03–1.13)

0.001

Ethnicity

 Caucasian

1.00

0.001

  

 Black

0.97 (0.68–1.39)

 Aboriginal

0.75 (0.55–1.01)

 Other

1.23 (1.07–1.40)

 Unknown

1.13 (1.03–1.25)

History of IDU

 No

1.00

<0.001

1.00

<0.001

 Yes

0.70 (0.60–0.83)

0.71 (0.60–0.85)

 Unknown

0.63 (0.44–0.89)

0.71 (0.50–1.02)

Era of cART initiation

 2000–03

1.00

<0.001

1.00

<0.001

 2004–07

1.24 (1.11–1.39)

1.26 (1.11–1.42)

 2008–12

1.42 (1.27–1.58)

1.32 (1.17–1.48)

Initial 3rd ARV class

 NNRTI

1.00

<0.001

1.00

<0.001

 Unboosted PI

0.53 (0.42–0.67)

0.60 (0.48–0.76)

 Boosted PI

0.82 (0.75–0.90)

0.81 (0.74–0.90)

 Other

0.81 (0.67–0.97)

0.83 (0.69–1.00)

Baseline AIDS-defining illness

 No

1.00

0.011

  

 Yes

0.84 (0.74–0.94)

 Unknown

1.04 (0.84–1.29)

Baseline viral load (per log10 copies/mL)

0.73 (0.66–0.80)

<0.001

0.73 (0.66–0.80)

<0.001

Baseline CD4 count (per 100 cells/mm3)

1.04 (1.02–1.07)

<0.001