World-wide variation in incidence of Acinetobacter associated ventilator associated pneumonia: a meta-regression

James C. Hurley

doi:10.1186/s12879-016-1921-4

Table 1 Characteristics of studies^a

From: World-wide variation in incidence of Acinetobacter associated ventilator associated pneumonia: a meta-regression

	Multinational	Europe^b	Mediterranean^b	Asia^b	Middle East^b	Central & South America^b	USA/Canada^b	Ungrouped^b
Sources [ref]	Additional file 1: Table S1 [S1-S4]	Additional file 1: Table S2 [S5-S37]	Additional file 1: Table S3 [S38-S57]	Additional file 1: Table S4 [S58-S64]	Additional file 1: Table S4 [S65-S73]	Additional file 1: Table S5 [S74-S81]	Additional file 1: Table S5 [S82-S96]	Additional file 1: Table S6 [S97-S100]
Number of groups	13	35	20	7	11	9	18	4
MV for >48 h for <75 %^c	0	1	1	1	0	1	2	0
Trauma ICUs^d	1	2	6	0	4	0	6	0
Bronchoscopic sampling^e	3	18	13	1	1	1	7	1
Intervention period	1	2	0	0	1	1	1	0
Study publication year (range)	1993-2012	1988-2016	1987-2012	2001-2016	2000-2013	1995-2013	1987-2014	1987-2015
Numbers of patients per study group; median (IQR)	2082; 1029-3413	385; 145-764	194; 101-318	952; 301-16426	260; 100-724	270; 233-427	340; 277-678	174; 65-331
Duration of MV (days); median (IQR)	6; 5-7	11; 7.4-14	8; 6.5-10.2	7.5; 6-9	8.9; 7.1-10	9.6; 7.6-10	5.5; 4–10.5	9.2; 4–10.6
VAP incidence;
• per 1000 ventilator days; o mean; ^f o 95 % CI	30 · 6; 20 · 4–40 · 7	24 · 3; 18 · 1–30 · 4	29.8 % 21 · 4–38 · 2	29 · 7; 15.9–43 · 5	34 · 0; 22.9–44 · 9	31 · 5; 19 · 3–43 · 6	26 · 7; 17 · 9–35 · 5	33 · 7; 15 · 4–51 · 9
Acinetobacter (all) VAP incidence^g
• per 1000 ventilator days; o mean; ^h o 95 % CI	4 · 2; 2 · 8–6 · 2	1 · 3; 0.7–2 · 5	3 · 5; 2.0–6 · 1	5.5; 2 · 4–12 · 8	8.8; 6 · 2–12 · 7	3 · 3; 1 · 8–6 · 2	1 · 2; 0 · 8–2 · 1	3 · 1; 1 · 9–5 · 2
Acinetobacter baumanii VAP incidence ⁱ
• per 1000 ventilator days; o mean; ^j o 95 % CI	8 · 2; 0 · 7–3 · 5	0 · 51; 0.1–0 · 9	2 · 8; 1 · 4–5 · 4	6.6; 2 · 1–20 · 1	18.0; 9 · 8–33 · 1	4 · 4; 2 · 0–10 · 0	1 · 2; 0 · 6–2 · 6

^aAbbreviations; ICU, Intensive care unit; MV; Mechanical ventilation; NA not applicable; VAP ventilator associated pneumonia; IQR, interquartile range
^bEurope includes France, Germany, United Kingdom, Switzerland, Sweden, Iceland, and Poland; Mediterranean includes Spain, Italy, Greece and Tunisia; Asia includes China, India, Pakistan and Bangladesh; Middle East includes Turkey, Iraq, Lebanon and Saudi Arabia; Central & South America includes Argentina, Brazil, Chile, Colombia, Cuba and Guatemala; Northern America includes USA and Canada; Ungrouped includes Australia and South Africa
^cStudies for which less than 75 % of patients were reported to receive more than 48 h of mechanical ventilation
^dTrauma ICU defined as an ICU with >50 % of patient admissions for trauma
^eBronchoscopic versus tracheal sampling toward the diagnosis of VAP
^fMean VAP incidence (per 1000 MV days) was not significantly different between the six geographic regions; p = 0.74
^gAcinetobacter (all) refers to Acinetobacter regardless of whether listing in the original study was as Acinetobacter species, Acinetobacter baumanii, or other speciation
^hMean Acinetobacter VAP incidence (per 1000 MV days) was significantly different between the six geographic regions; p = 0.003
ⁱOnly from those studies that specified Acinetobacter baumanii
^jMean Acinetobacter VAP incidence from studies reporting as Acinetobacter baumanii (per 1000 MV days) was significantly different between the six geographic regions; p = 0.014

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