Klebsiella pneumoniae bloodstream infections at a South African children’s hospital 2006–2011, a cross-sectional study

Table 7 Factors associated with 30-day inpatient mortality in children with Klebsiella pneumoniae bloodstream infection

Risk factors for death	Alive	Died	Univariate analysis		Adjusted RR^a for mortality (n = 259)
Risk factors for death	n/N (%)	n/N (%)	RR^a (95 % CI)	p-value	aRR (95 % CI)	p-value
ESBL-KPBSI	210/267 (78.7)	100/109 (91.7)	2.36 (1.26–4.43)	0.00	1.09 (0.55–2.16)	0.80
Moderate or severe underweight-for-age	150/267 (56.2)	71/109 (65.1)	1.31 (0.94–1.83)	0.11	1.12 (0.79–1.62)	0.54
HIV-infection**	38/181 (21.0)	37/83 (44.6)	2.03 (1.44–2.85)	<0.001	2.44 (1.59–3.74)	<0.001
Patient in the PICU at time of BSI**	56/267 (21.7)	31/109 (28.4)	1.28 (0.91–1.80)	0.16	1.64 (1.03–2.61)	0.04
Patient needing to go to PICU at the time of KP bloodstream infection**	44/267 (16.5)	34/109 (31.2)	1.73 (1.26–2.38)	0.001	1.72 (1.10–2.70)	0.02
Continuous IV infusion for >3 days before the BSI	174/264 (65.9)	73/108 (67.6)	1.06 (0.75–1.48)	0.76	0.93 (0.64–1.35)	0.70
BSI without source**	145/266 (54.5)	41/108 (38.0)	0.61 (0.44–0.86)	0.004	0.82 (0.55–1.22)	0.33
Chronic underlying medical condition excluding HIV infection	124/267 (46.4)	41/109 (37.6)	0.77 (0.56–1.07)	0.12	1.30 (0.81–2.08)	0.28
Skin erosions**	70/265 (26.4)	47/108 (43.5)	1.69 (1.24–2.30)	0.001	2.15 (1.54–3.0)	<0.001

n/N stratum specific proportions; **p-value ≤ 0.05; RR risk ratio
ESBL KP BSI Extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae bloodstream infection, PICU paediatric intensive care unit, aRR adjusted risk ratio *:Multivariate model adjusted for age, gender, nutrition, HIV infection, ESBL, Patient in PICU, patient needing to go to PICU, continuous IV infusion for >3 days before the BSI, KPBSI without source, chronic underlying medical condition excluding HIV, and skin erosions

ISSN: 1471-2334