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Table 2 Susceptibility (of bacteria from blood cultures taken from neonates less than 48 h old) to antimicrobials used for empiric treatment of neonatal BSI

From: Neonatal bloodstream infections in a Ghanaian Tertiary Hospital: Are the current antibiotic recommendations adequate?

Organisms Susceptibility
  Ampicillin + Gentamicin (A) Ampicillin + Cefotaxime (B) Cloxacillin + Gentamicin (C) Regimen coverage
  Number of isolates Number Tested (%) Number susceptible (%) Number Tested (%) Number susceptible (%) Number Tested (%) Number susceptible (%)
Gram negatives 109 101 (92.6) 38 (37.6)a 68 (62.4) 32 (47.1)a 75 (68.8) 52 (69.3)b C > B = A; p = 0.001
Enterobacteriacea 79 74 (93.7) 24 (32.4) 55 (69.6) 27 (49.1) 53 (67.1) 37 (69.8)  
Acinetobacter species 16 16 (100) 10 (62.5) 13 (81.2) 5 (38.4) 13 (81.2) 8 (61.5)  
Pseudomonas species 11 11 (100) 4 (36.4) - - 9 (81.8) 7 (77.7)  
 Others 3        
Gram positives 610 511 (83.8) 159 (31.1)b 356 (58.4) 56 (15.7)a 211 (34.6) 153 (72.5)b C > A > B; p = 0.001
Enterococcus species 43 37 (86.1) 8 (21.6) 37 (86.1) 7 (18.9) - -  
Staphylococcus aureus 76 67 (88.2) 34 (50.7) 59 (77.6) 5 (8.5) 69 (90.7) 46 (66.7)  
 CoNS 431 376 (87.2) 107 (28.5) 226 (52.4) 26 (11.5) 111 (25.7) 93 (83.7) C > A > B; p = 0.001
Streptococcus species 59 31 (52.5) 10 (32.3) 34 (57.6) 18 (30.5) 31 (52.5) 14 (45.2)  
 Others 1        
Total 719 612 (85.1) a197 (32.2)b 424 (58.9) a 88 (20.7) a 286 (40.0) a205 (71.7)c C > A > B; p = 0.001
Total excluding CoNS 288 236 (81.9) a90 (38.1)a 198 (68.8) b 62 (31.3)a 175 (60.7) a112 (64.0)b C > B = A; p = 0.001
Polymicrobial infections 20 19 (95.0) 4 (21)a 18 (90.0) 2 (11.1)a 20 (100.0) 5 (25.0)a C = B = A; p = 0.540
 2 organisms 17 16 (94.1) 1 (6.3) 15 (88.2) 1 (6.7) 17 (100) 4 (23.5)  
 3 organisms 3 3 (100) 3 (100) 3 (100) 1 (33.3) 3 (100) 1 (33.3)  
  1. Based on in-vitro susceptibility. Data on isolates with insufficient numbers (n ≤ 5) not shown. For polymicrobial infections, all isolates were susceptible to at least one of the treatment antibiotics
  2. A, Ampicillin plus Gentamicin; B, Ampicillin plus cefotaxime; C, Cloxacillin plus gentamicin; CoNS, Coagulase negative Staphylococcus species. Other Gram-negatives included Neisseria species (n = 1), Stenophromonas species (n = 1) and Moraxella species (n = 1). Other Gram-positives included Micrococcus species
  3. Differing superscripts across row denotes differences in the proportion of susceptible isolates to antimicrobial regimen. Differences in proportions computed by Chi square with Marascuilo’s Post Hoc Multiple proportion comparisons at p-value <0.05. Differing subscripts within a column denotes differences in the proportion of susceptible isolates to antimicrobial regimen