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Table 4 Serum GNLY concentrations and other factors associated with IGRA-positive status in univariate and multivariate logistic regression models (n = 109)

From: Circulating granulysin levels in healthcare workers and latent tuberculosis infection estimated using interferon-gamma release assays

 

No (%)

Univariate

Multivariatea

  

OR

95 % CI

OR

95 % CI

Age (by year)

 

1.02

0.98–1.06

1.03

0.98–1.09

Sex

 Male

11/26 (42.3)

Reference

 

Reference

 

 Female

30/83 (36.1)

0.77

0.31–1.89

0.83

0.26–2.65

BMI

 18.5–24.9

31/92 (33.7)

Reference

 

Reference

 

 < 18.5

3/7 (42.9)

1.48

0.31–7.01

3.99

0.53–29.92

 ≥ 25.0

7/10 (70.0)

4.59

1.11–18.99

8.43

1.37–51.75

Job

 Others

4/22 (18.2)

Reference

 

Reference

 

 Doctor

10/19 (52.6)

5.00

1.22–20.46

3.37

0.69–16.52

 Nurse

22/55 (40.0)

3.00

0.89–10.06

2.51

0.56–11.18

 Technician

5/13 (38.5)

2.81

0.59–13.34

1.48

0.22–10.03

Working place

 Non-TB

8/30 (26.7)

Reference

 

Reference

 

 TB

32/77 (41.6)

1.96

0.77–4.94

1.70

0.55–5.22

GNLY concentration (by ng/ml)

0.55

0.35–0.89

0.55

0.31–0.98

GNLY mRNA expression (by one unit)

0.95

0.88–1.02

0.98

0.88–1.08

Genotype (by number of C allele)

0.84

0.47–1.51

-

-

  1. GNLY granulysin, IGRA interferon-gamma release assays, OR odds ratio, 95 % CI 95 % confidence interval, BMI body mass index, TB tuberculosis; significant associations are presented in bold
  2. aMultivariate analyses included age, sex, BMI, job category, working place, GNLY concentration, and GNLY mRNA expression levels