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Table 4 Mutations in the rpoB, katG, pncA and embB genes with the associated MICs and genotypes of the XDR isolates

From: Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa

Isolate

Genotype

MIC (mg/L)

Mutation Profile

aAssociated amino acid substitutions

RIF

INH

EMB

rpoB

katG

pncA

embB

TF1762

KZN

16

8

16

A1304G

T1355C

G944C

ΔC

A916G

MODS141

KZN

128

8

16

A1304G

T1355C

G944C

ΔC

A916G

MODS39

KZN

32

4

2

A1304G

T1355C

G944C

ΔC

A916G

MODS387

KZN

128

16

8

A1304G

T1355C

G944C

ΔC

A916G

MODS338

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

MODS667

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

MODS513

KZN

128

8

16

A1304G

T1355C

G944C

ΔC

A916G

MODS143

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF1824

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF1925

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF66937

KZN

128

16

8

A1304G

T1355C

G944C

ΔC

A916G

TF80198

KZN

128

16

8

A1304G

T1355C

G944C

ΔC

A916G

TF80164

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF1497

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF75549

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF31066

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF739

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

MODS370

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF3181

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF37806

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

TF2981

KZN

128

16

16

A1304G

T1355C

G944C

ΔC

A916G

MODS334

KZN

128

16

16

-

-

G944C

ΔC

A916G

TF2038

KZN

128

16

16

A1304G

-

G944C

ΔC

A916G

TF3228

KZN

128

16

16

-

-

G944C

ΔC

A916G

TF25027

KZN

128

16

8

A1304G

-

G944C

ΔC

A916G

TF51648

KZN

128

16

16

A1304G

-

G944C

ΔC

A916G

TF49127

KZN

64

16

16

A1304G

-

G944C

ΔC

A916G

MODS 195

KZN

32

16

8

A1304G

-

G944C

ΔC

A916G

  1. a rpoB:A1304G = D435G; T1355C = L452P
  2. katG: G944C = S315T
  3. pncA: ΔC = Insertion of cytosine at position 457
  4. embB: A916G = M306V; C1489A = Q506K