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Table 4 Mutations in the rpoB, katG, pncA and embB genes with the associated MICs and genotypes of the XDR isolates

From: Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa

Isolate Genotype MIC (mg/L) Mutation Profile
aAssociated amino acid substitutions
RIF INH EMB rpoB katG pncA embB
TF1762 KZN 16 8 16 A1304G T1355C G944C ΔC A916G
MODS141 KZN 128 8 16 A1304G T1355C G944C ΔC A916G
MODS39 KZN 32 4 2 A1304G T1355C G944C ΔC A916G
MODS387 KZN 128 16 8 A1304G T1355C G944C ΔC A916G
MODS338 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
MODS667 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
MODS513 KZN 128 8 16 A1304G T1355C G944C ΔC A916G
MODS143 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF1824 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF1925 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF66937 KZN 128 16 8 A1304G T1355C G944C ΔC A916G
TF80198 KZN 128 16 8 A1304G T1355C G944C ΔC A916G
TF80164 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF1497 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF75549 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF31066 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF739 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
MODS370 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF3181 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF37806 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
TF2981 KZN 128 16 16 A1304G T1355C G944C ΔC A916G
MODS334 KZN 128 16 16 - - G944C ΔC A916G
TF2038 KZN 128 16 16 A1304G - G944C ΔC A916G
TF3228 KZN 128 16 16 - - G944C ΔC A916G
TF25027 KZN 128 16 8 A1304G - G944C ΔC A916G
TF51648 KZN 128 16 16 A1304G - G944C ΔC A916G
TF49127 KZN 64 16 16 A1304G - G944C ΔC A916G
MODS 195 KZN 32 16 8 A1304G - G944C ΔC A916G
  1. a rpoB:A1304G = D435G; T1355C = L452P
  2. katG: G944C = S315T
  3. pncA: ΔC = Insertion of cytosine at position 457
  4. embB: A916G = M306V; C1489A = Q506K