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Table 3 Hospitalizations, General Practitioner Visits, and Treatment Costsa Associated with HZ and PHN

From: Increasing incidence associated with herpes zoster infection in British Columbia, Canada

  Pre-licensure Privately Funded Publicly Funded Overall
  1997–1999 1999–2004 2005–2012 1997–2012
  (3 years) (6 years) (8 years) (16 years)
Initial HZ Cases Identified Based on Hospitalization or GP Visits
 Hospitalization (Annual count, %) 409 (3.5 %) 296 (2.3 %) 276 (1.6 %) 300 (2 %)
 Annual Cost $4,747,242 $4,290,917 $5,428,559 $4,916,779
 Cost/hospitalization Case $11,607 $14,505 $19,678 $16,389
 GP Visit (Annual count, %) 11408 (96.5 %) 12519 (97.7 %) 16946 (98.4 %) 14593 (98 %)
 Annual Cost $451,523 $475,046 $605,407 $537,286
 Cost/GP Case $40 $38 $36 $37
 Number of Cases Treated (Annual count, %)b 4889 (41.4 %) 6281 (49 %) 9987 (58 %) 7960 (53.4 %)
 Annual Treatment Costs $750,370 $896,161 $1,091,457 $975,585
 Cost/Rx Case $153 $143 $109 $123
 Overall Annual Cost $5,949,134 $5,662,124 $7,125,422 $6,429,649
 Overall Cost/Case $503 $442 $414 $432
HZ Related Hospitalization or GP Visits within 90 days Post Initial HZ Diagnosis
Hospitalization
 Annual Casesc with ≥1 admission 109 (0.9 %) 84 (0.7 %) 93 (0.5 %) 91 (0.6 %)
 Annual Cases with 0 admission 11708 (99.1 %) 12732 (99.3 %) 17129 (99.5 %) 14802 (99.4 %)
 Annual Cost $1,164,402 $963,319 $1,381,308 $1,197,449
 Cost/Admission $9,785 $10,763 $13,779 $12,149
GP Visits
 Annual Casesc with ≥1 Visit 3207 (27.1 %) 3316 (25.9 %) 4588 (26.6 %) 3938 (26.4 %)
 Annual Cases with 0 Visit 8610 (72.9 %) 9500 (74.1 %) 12634 (73.4 %) 10956 (73.6 %)
 Annual Visits 8168 7602 12659 10201
 Annual Visits with Rxd 1289 1458 2925 2170
 Annual Visit Cost $219,145 $218,276 $289,042 $253,768
 Annual Rx Cost $112,653 $122,106 $219,036 $169,389
 Annual Cost (Visit + Rx) $331,798 $340,382 $508,078 $423,157
 Cost/Visit (including Rx cost) $41 $45 $40 $41
PHN Related Hospitalization or GP Visits within 90 days Post Initial HZ Diagnosis
Hospitalization
 Annual Casesc with ≥1 admission 39 (0.3 %) 35 (0.3 %) 37 (0.2 %) 37 (0.2 %)
 Annual Cases with 0 admission 11778 (99.7 %) 12780 (99.7 %) 17184 (99.8 %) 14857 (99.8 %)
 Annual Admission 43 38 40 39
 Annual Cost $360,725 $539,429 $610,727 $552,740
 Cost/Admission $8,488 $14,196 $15,364 $14,016
GP Visits
 Annual Casesc with ≥1 Visit 416 (3.2 %) 614 (4.8 %) 1192 (6.9 %) 878 (5.9 %)
 Annual Cases with 0 Visit 11410 (96.6 %) 12201 (95.2 %) 16029 (93.1 %) 14015 (94.1 %)
 Annual Visits 606 901 2015 1421
 Annual Visits with Rxe 478 751 1514 1098
 Annual Visit Cost $5,693 $6,596 $19,048 $12,709
 Annual Rx Cost $17,011 $39,874 $91,544 $62,851
 Annual Cost (Visit + Rx) $22,704 $46,470 $110,592 $75,560
 Cost/Visit $37 $52 $55 $53
  1. aAll Costs were adjusted to 2013 British Columbia Consumer Price Index, Health and Personal Care
  2. bPrescriptions on the same day of GP visits related to initial HZ treatment were antivirals (94.5 %), anticonvulsants (5.5 %), antidepressants (3.9 %), corticosteroids (2.6 %), NSAIDS (2.5 %), immunosuppressants (0.1 %), non-NSAID analgesia (0.0 %)
  3. cCase refers to the number of patients with at least one related PHN or HZ hospital admission or GP visits 90 days after initial HZ diagnosis
  4. dPrescriptions on the same day of GP visits related to HZ treatment were anticonvulsants (40.3 %), antivirals (38.6 %), antidepressants (18.3 %), NSAIDS (6.8 %), corticosteroids (6.5 %), immunosuppressants (0.2 %), non-NSAID analgesia (0.1 %)
  5. ePrescription on the same day of GP visits related to PHN were anticonvulsants (61.7 %), antidepressants (27.9 %), NSAIDS (9.8 %), corticosteroids (8.7 %), antivirals (7.5 %), non-NSAID analgesia (0.2 %), immunosuppressant (0.2 %)