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Table 3 Hospitalizations, General Practitioner Visits, and Treatment Costsa Associated with HZ and PHN

From: Increasing incidence associated with herpes zoster infection in British Columbia, Canada

 

Pre-licensure

Privately Funded

Publicly Funded

Overall

 

1997–1999

1999–2004

2005–2012

1997–2012

 

(3 years)

(6 years)

(8 years)

(16 years)

Initial HZ Cases Identified Based on Hospitalization or GP Visits

 Hospitalization (Annual count, %)

409 (3.5 %)

296 (2.3 %)

276 (1.6 %)

300 (2 %)

 Annual Cost

$4,747,242

$4,290,917

$5,428,559

$4,916,779

 Cost/hospitalization Case

$11,607

$14,505

$19,678

$16,389

 GP Visit (Annual count, %)

11408 (96.5 %)

12519 (97.7 %)

16946 (98.4 %)

14593 (98 %)

 Annual Cost

$451,523

$475,046

$605,407

$537,286

 Cost/GP Case

$40

$38

$36

$37

 Number of Cases Treated (Annual count, %)b

4889 (41.4 %)

6281 (49 %)

9987 (58 %)

7960 (53.4 %)

 Annual Treatment Costs

$750,370

$896,161

$1,091,457

$975,585

 Cost/Rx Case

$153

$143

$109

$123

 Overall Annual Cost

$5,949,134

$5,662,124

$7,125,422

$6,429,649

 Overall Cost/Case

$503

$442

$414

$432

HZ Related Hospitalization or GP Visits within 90 days Post Initial HZ Diagnosis

Hospitalization

 Annual Casesc with ≥1 admission

109 (0.9 %)

84 (0.7 %)

93 (0.5 %)

91 (0.6 %)

 Annual Cases with 0 admission

11708 (99.1 %)

12732 (99.3 %)

17129 (99.5 %)

14802 (99.4 %)

 Annual Cost

$1,164,402

$963,319

$1,381,308

$1,197,449

 Cost/Admission

$9,785

$10,763

$13,779

$12,149

GP Visits

 Annual Casesc with ≥1 Visit

3207 (27.1 %)

3316 (25.9 %)

4588 (26.6 %)

3938 (26.4 %)

 Annual Cases with 0 Visit

8610 (72.9 %)

9500 (74.1 %)

12634 (73.4 %)

10956 (73.6 %)

 Annual Visits

8168

7602

12659

10201

 Annual Visits with Rxd

1289

1458

2925

2170

 Annual Visit Cost

$219,145

$218,276

$289,042

$253,768

 Annual Rx Cost

$112,653

$122,106

$219,036

$169,389

 Annual Cost (Visit + Rx)

$331,798

$340,382

$508,078

$423,157

 Cost/Visit (including Rx cost)

$41

$45

$40

$41

PHN Related Hospitalization or GP Visits within 90 days Post Initial HZ Diagnosis

Hospitalization

 Annual Casesc with ≥1 admission

39 (0.3 %)

35 (0.3 %)

37 (0.2 %)

37 (0.2 %)

 Annual Cases with 0 admission

11778 (99.7 %)

12780 (99.7 %)

17184 (99.8 %)

14857 (99.8 %)

 Annual Admission

43

38

40

39

 Annual Cost

$360,725

$539,429

$610,727

$552,740

 Cost/Admission

$8,488

$14,196

$15,364

$14,016

GP Visits

 Annual Casesc with ≥1 Visit

416 (3.2 %)

614 (4.8 %)

1192 (6.9 %)

878 (5.9 %)

 Annual Cases with 0 Visit

11410 (96.6 %)

12201 (95.2 %)

16029 (93.1 %)

14015 (94.1 %)

 Annual Visits

606

901

2015

1421

 Annual Visits with Rxe

478

751

1514

1098

 Annual Visit Cost

$5,693

$6,596

$19,048

$12,709

 Annual Rx Cost

$17,011

$39,874

$91,544

$62,851

 Annual Cost (Visit + Rx)

$22,704

$46,470

$110,592

$75,560

 Cost/Visit

$37

$52

$55

$53

  1. aAll Costs were adjusted to 2013 British Columbia Consumer Price Index, Health and Personal Care
  2. bPrescriptions on the same day of GP visits related to initial HZ treatment were antivirals (94.5 %), anticonvulsants (5.5 %), antidepressants (3.9 %), corticosteroids (2.6 %), NSAIDS (2.5 %), immunosuppressants (0.1 %), non-NSAID analgesia (0.0 %)
  3. cCase refers to the number of patients with at least one related PHN or HZ hospital admission or GP visits 90 days after initial HZ diagnosis
  4. dPrescriptions on the same day of GP visits related to HZ treatment were anticonvulsants (40.3 %), antivirals (38.6 %), antidepressants (18.3 %), NSAIDS (6.8 %), corticosteroids (6.5 %), immunosuppressants (0.2 %), non-NSAID analgesia (0.1 %)
  5. ePrescription on the same day of GP visits related to PHN were anticonvulsants (61.7 %), antidepressants (27.9 %), NSAIDS (9.8 %), corticosteroids (8.7 %), antivirals (7.5 %), non-NSAID analgesia (0.2 %), immunosuppressant (0.2 %)