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Table 2 Clinical and laboratory characteristics of patients with tuberculous spondylitis and culture negative pyogenic spondylitis

From: Comparison of characteristics of culture-negative pyogenic spondylitis and tuberculous spondylitis: a retrospective study

  CNPS (N = 71) TS (N = 94) P-value
Duration of symptoms
 <1 month 32 (45.1 %) 25 (26.6 %) 0.002
 1–3 months 32 (45.1 %) 44 (46.8 %)
 > 4 months 7 (9.9 %) 25 (26.6 %)
Neurologic stage
 No pain 0 3 (3.2 %) 0.164
 Spine pain 28 (39.4 %) 52 (55.3 %)
 Radiating pain 38 (53.5 %) 26 (26.6 %)
 Weakness 5 (7.0 %) 13 (13.8 %)
Sepsis 7 (9.9 %) 15 (16.0 %) 0.254
Initial body temperature over 38 °C 11 (15.5 %) 27 (31.8 %) 0.018
WBC (/mm3) (median with IQR) 8600 (7070–11,100) 7890 (6098–10,293) 0.030
CRP a (mg/dL) (median with IQR) 4.3 (2.4–8.1) 2.8 (1.0–7.2) 0.018
IGRA b
 Positive 8 (27.6 %) 38 (79.2 %) <0.001
 Negative 19 (65.5 %) 9 (18.8 %)
Psoas abscess 11 (15.5 %) 31 (33.0 %) 0.011
Paravertebral abscess 35 (49.3 %) 70 (74.5 %) 0.001
Epidural abscess 39 (54.9 %) 50 (53.2 %) 0.824
Involved vertebrae
 Cervical 2 (2.8 %) 3 (3.2 %) N.A.
 Cervicothoracic 0 6 (6.4 %)
 Thoracic 5 (7.0 %) 25 (26.6 %)
 Thoracolumbar 3 (4.2 %) 9 (9.6 %)
 Lumbar 47 (66.2 %) 43 (45.7 %)
 Lumbosacral 14 (19.7 %) 6 (6.4 %)
 Sacral 0 1 (1.1 %)
 Cervical and Lumbar (skipped lesion) 0 1 (1.1 %)
Number of vertebrae involved
 1–2 58 (81.7 %) 65 (69.1 %) 0.067
 3–5 13 (18.3 %) 29 (30.9 %)
  1. Abbreviations: WBC white blood cell count, IQR interquartile range, CRP C-reactive protein, IGRA Interferon gamma release assay, TS tuberculous spondylitis, CNPS culture negative pyogenic spondylitis, N.A not applicable
  2. aC-Reactive Protein value was missing in 1 case of tuberculous spondylitis
  3. bThe IGRA was performed in 76 patients: 48 with TS and 29 with CNPS. IGRA result was indeterminate in one case of tuberculous spondylitis and two cases of culture negative pyogenic spondylitis