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Table 3 Poisson regression models for baseline factors associated with overall mortality

From: Risk factors for mortality among malnourished HIV-infected adults eligible for antiretroviral therapy

Factor

Level

Unadjusted HR (95 % CI) b

p-value

Adjusted HR (95 % CI) c n = 1685c

Adjusted p-value

Site

Zambia

1

<0.001

1

<0.001

Tanzania

1.90 (1.55 to 2.33)

 

1.60 (1.27 to 2.03)

 

Sex

Female

1

0.002

1

<0.001

Male

1.38 (1.12 to 1.70)

 

2.05 (1.60 to 2.64)

 

Age group (years)

18–29

1

0.43

1

0.79

30–39

1.09 (0.84 to 1.42)

 

1.01 (0.77 to 1.34)

 

40–49

1.03 (0.76 to 1.39)

 

0.94 (0.67 to 1.30)

 

> = 50

1.35 (0.93 to 1.97)

 

0.84 (0.55 to 1.28)

 

Socioeconomic quintiles

Highest

1

0.65

  
 

High

1.09 (0.79 to 1.50)

   

Middle

0.99 (0.72 to 1.37)

   

Low

1.10 (0.80 to 1.51)

   

Lowest

0.87 (0.62 to 1.22)

   

CD4 group (cells/μl)

> = 200

1

<0.001

1

<0.001

100–199

1.34 (0.96 to 1.87)

 

1.19 (0.84 to 1.69)

 

50–99

2.33 (1.67 to 3.24)

 

1.69 (1.19 to 2.40)

 

<50

2.98 (2.19 to 4.04)

 

2.10 (1.52 to 2.91)

 

BMIa

Per 1 kg/m2 increase

0.76 (0.71 to 0.81)

<0.001

0.85 (0.78 to 0.91)

<0.001

Haemoglobin

Per 10 g/L increase

0.82 (0.78 to 0.86)

<0.001

  

Oedema

No

1

<0.001

1

0.004

Yes

3.01 (2.07 to 4.38)

 

1.84 (1.21 to 2.78)

 

Baseline TBa treatment

No

1

<0.001

1

<0.001

Yes

0.54 (0.39 to 0.76)

 

0.44 (0.31 to 0.63)

 

Baseline cotrimoxazole treatment

No

1

0.41

  

Yes

1.13 (0.85 to 1.49)

   

CRPa (mg/l)

<10

1

<0.001

1

<0.001

10–49

1.77 (1.12 to 2.80)

 

1.61 (1.00 to 2.58)

 

50–159

3.80 (2.50 to 5.78)

 

3.03 (1.97 to 4.66)

 

≥160

5.43 (3.61 to 8.18)

 

3.67 (2.40 to 5.62)

 

Fat-free mass index

Per 1 kg/m2 increase

0.76 (0.66 to 0.88)

<0.001

0.80 (0.67 to 0.95)

0.01

Fat mass index

Per 1 kg/m2 increase

0.75 (0.64 to 0.88)

0.001

0.86 (0.70 to 1.05)

0.15

Grip strength

Per 1 kg increase

0.94 (0.93 to 0.96)

<0.001

0.94 (0.92 to 0.96)

<0.001

MUACa

Per 1 cm increase

0.78 (0.74 to 0.82)

<0.001

0.87 (0.82 to 0.92)

<0.001

Appetite score

> − 0.5

1

0.004

1

0.65

−1.49 to−0.55

1.30 (0.89 to 1.91)

 

1.20 (0.81 to 1.78)

 

<−1.5

1.83 (1.27 to 2.62

 

1.08 (0.72 to 1.61)

 

Phosphate (mmol/l)

Cubic spline

 

0.001

 

0.40

  1. aAbbreviations: BMI body mass index, MUAC mid-upper arm circumference, CRP C-reactive protein, TB tuberculosis
  2. bn = 1815 except haemoglobin n = 1670, CRP n = 1762, fat-free mass n = 1461, grip strength n = 1752, MUAC n = 1802, appetite n = 684 (Tanzanian patients only), phosphate n = 1764
  3. cMultivariable analysis adjusted for age, sex, CD4, BMI, oedema, TB treatment, CRP, grip strength, site, follow-up time in 3 week bands (association with mortality p < 0.002 except in appetite analysis p = 0.24) and study arm. Association with fat-free mass, MUAC and appetite not adjusted for BMI. n = 1685 except fat-free mass n = 1349, MUAC n = 1672, appetite n = 630, (Tanzanian patients only), Phosphate n = 1644