Skip to main content

Table 8 Summary of the main clinical studies evaluating sTREM-1 prognostic value

From: Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

  Gibot et al. 2005 [16] Giamarellos-Bourboulis et al. 2006 [19] Zhang et al. 2011 [23] Jeong et al. 2012 [15] Su et al. 2012 [24] Li et al. 2014 [13] Ravetti et al. 2015 [17] Our study
Nb. of Patients 63 90 52 63 130 (100 with sepsis) 102 40 with cancer 190
Median Age 61 Unknown Unknown 63.7 58.9 63 67 60.6
Unit ICU ICU ICU ER (and then ICU) ICU ICU ICU ICU
Severity of sepsis Septic shock (53 %) Severe sepsis + Septic shock (70 %) Severe sepsis + Septic shock (71.1 %) Severe sepsis + Septic shock (100 %) Severe sepsis + Septic shock (64 %) Sepsis, Severe sepsis and Septic shock Severe sepsis + Septic shock (100 %) Septic shock (68.4 %)
Site of Infection Miscellaneous VAP Miscellaneous Miscellaneous Miscellaneous Miscellaneous Miscellaneous Miscellaneous
Overall Mortality 33 % (ICU) 36.7 % 30.7 % (D28) 25.4 % (D28) 43 % (D28) 41.2 % (D28) In cancer patients: 25.8 % (ICU)
34.7 % (ICU)
40 % (D28)
SAPS II 53 (21) Unknown Unknown Unknown Unknown Unknown Unknown 52.6 (21.5)
APACHE 2 Unknown Unknown Unknown Unknown 13.4 (6.1) Unknown In cancer patients 19.9 (5.1) Unknown
SOFA D0 936 (3.1) Unknown Unknown Unknown 7.8 (4.4) Unknown 6.2 (2.7) 9 (5.2)
Type of sample - sTREM1 - Serum - Serum - Serum - Serum - Serum - Serum - Serum
- sTREM1 - sTREM1 - sTREM1 - sTREM1 - sTREM1 - sTREM1 - sTREM1
- ELISA - ELISA - ELISA - ELISA - ELISA - ELISA - ELISA
Median sTREM1 level on admission (pg/ml)        In Cancer Patients  
Survivors 154 Unknown 193.4 182.4 Unknown 161.95 848 671
Non survivors 94 (p = 0.02) Unknown 240.2 (NS) 514.1 (p = 0.001) Unknown 320 (p < 0.001) 558 (NS) 1148 (p < 0.01)
sTREM1 cut-off value (pg/ml) 180 (baseline)      252.05 (baseline)   954.4 (baseline)
Sensitivity 86 %      85.7 %   54.5 %
Specificity 70 %      75.7 %   78 %
AUROCC 0.74      0.856   0.64
PPV       70.6 %   49.2 %
NPV       88.2 %   81.5 %
Best Relevant Prognostic Predictor (associated with sTREM1) -sTREM1 baseline - sTREM1/IL-6 baseline ratio None (sTREM1 increase between D1 and D14 was NS) - Log (sTREM1) baseline None sTREM1 (baseline > 252.05) -sTREM1 value on D2 for ICU mortality. AUROCC = 0.69 sTREM1 (baseline value > 954.4) + SAPS II (>67.5)
Other relevant Predictors - SOFA baseline - TNF alpha baseline - SOFA score baseline and evolution - ScVO2 baseline    - sTREM1 value on D1 for D28 mortality. AUROCC = 0.75  
- IL-6 baseline - SAPS II - SOFA - PCT (baseline > 10.6 ng/ml) - Days of MV - SAPS II
- IL-10/IL-6 baseline ratio - sCD163 - SOFA baseline > 6.5 - Use of corticosteroids - Core Temperature
  1. ICU Intensive Care Unit, ER Emergency Room, PPV Predictive Positive Value, NPV Negative Predictive Value, AUROCC area under receiver operating characteristics curve, sTREM-1 soluble triggering receptor expressed on myeloid cells-1, PCT procalcitonin, MV mechanical ventilation, SOFA sequential organ failure assessment, SAPS simplified acute physiologic score, NS not significant, ELISA enzyme-liked immuno-assay