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Table 7 Clinical performance of biomarkers in predicting SOFA score increase within the first 48 h of sepsis management in the ICU

From: Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

  AUROCC [95 % CI] Se (%) [95 % CI] Sp (%) [95 % CI] PPV (%) [95 % CI] NPV (%) [95 % CI] Positive LR [95 % CI] Negative LR [95 % CI]
sTREM-1 (>568.8 ng/L) 0.66 [0.56–0.76] 86.5 % [71.2–95.5] 45.8 % [35.6–56.3] 38.1 % [31.4–42.1] 89.8 % [69.7–100] 1.60 [1.10–2.18] 0.29 [0.08–0.81]
PCT (>3.9 ug/L) 0.61 [0.51–0.71] 88.2 % [72.5–96.7] 36.5 % [26.9–46.9] 33.0 % [27.1–33.1] 89.7 % [66.2–100] 1.39 [0.99–1.82] 0.32 [0.07–1.02]
Lactate (>3.1 mmol/L) 0.60 [0.51–0.68] 43.0 % [32.8–53.7] 76.6 % [66.7–84.7] 50.0 % [40.2–64.7] 75.8 % [60.1–76.3] 1.84 [0.98–3.44] 0.78 [0.56–1.01]
  1. AUROCC area under receiver operating characteristics curve, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, PCT procalcitonin, sTREM-1 soluble triggering receptor expressed on myeloid cells-1, SOFA sequential organ failure assessment, ICU intensive care unit