Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

Table 5 Clinical performance of sTREM-1 combined with either SAPS II or SOFA score values in predicting all cause ICU mortality

	AUROCC [95 % CI]	Se (%) [95 % CI]	Sp (%) [95 % CI]	PPV (%) [95 % CI]	NPV (%) [95 % CI]	Positive LR [95 % CI]	Negative LR [95 % CI]
sTREM-1 (>954.4 ng/L) & SAPS II (>67.5)	0.68 [0.59–0.78]	38.8 % [25.2–53.8]	98.6 % [95.0–99.8]	91.3 % [58.8–100]	80.3 % [79.3–83.3]	27.30 [5.08–261.50]	0.63 [0.48–0.78]
sTREM-1 (>954.4 ng/L) & SOFA D1 (>7.5)	0.70 [0.61–0.80]	55.1 % [40.2–69.3]	85.8 % [78.9–91.1]	57.4 % [41.9–72.2]	84.6 % [77.8–89.8]	3.88 [3.20–29.70]	0.57 [0.41–0.76]

AUROCC area under receiver operating characteristics curve, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, sTREM-1 soluble triggering receptor expressed on myeloid cells-1, SAPS simplified acute physiologic score, SOFA sequential organ failure assessment, ICU intensive care unit

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