Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

Table 4 Clinical performance of some biomarkers combinations in predicting all cause ICU mortality

	AUROCC [95 % CI]	Se (%) [95 % CI]	Sp (%) [95 % CI]	PPV (%) [95 % CI]	NPV (%) [95 % CI]	Positive LR [95 % CI]	Negative LR [95 % CI]
sTREM-1 (>954.4 ng/L) & PCT (>11.1 ug/L)	0.64 [0.54–0.73]	38.2 % [25.4–52.3]	89.4 % [83.1–93.9]	58.3 % [35.6–73.2]	78.7 % [75.6–85.4]	3.59 [1.50–8.57]	0.69 [0.51–0.90]
sTREM-1 (>954.4 ng/L) & Lactate (>3.2 mmol/L)	0.62 [0.53–0.72]	29.1 % [17.6–42.9]	95.7 % [91.0–98.4]	49.2 % [29.7–72.5]	83.8 % [79.7–86.2]	6.84 [1.95–26.80]	0.74 [0.58–0.90]

AUROCC area under receiver operating characteristics curve, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, PCT procalcitonin, sTREM-1 soluble triggering receptor expressed on myeloid cells-1, ICU intensive care unit

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