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Table 3 Clinical performance of biomarkers and clinical scoring systems in predicting all-cause ICU mortality

From: Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

 

AUROCC [95 % CI]

Se (%) [95 % CI]

Sp (%) [95 % CI]

PPV (%) [95 % CI]

NPV (%) [95 % CI]

Positive LR [95 % CI]

Negative LR [95 % CI]

sTREM-1 (>954.4 ng/L)

0.64 [0.54–0.74]

54.5 % [40.5–68.0]

78.0 % [70.3–84.5]

49.2 % [40.5–54.6]

81.5 % [70.3–92.4]

2.48 [1.36–4.39]

0.58 [0.37–0.85]

PCT (>11.1 ug/L)

0.62 [0.53–0.71]

66.7 % [52.5–78.9]

55.8 % [47.1–64.2]

37.1 % [28.3–42.5]

81.0 % [67.1–91.4]

1.51 [0.99–2.20]

0.60 [0.33–1.01]

Lactate (>3.2 mmol/L)

0.71 [0.62–0.80]

61.2 % [46.2–74.8]

78.3 % [70.4–84.8]

50.0 % [37.7–61.1]

84.8 % [70.4–92.0]

2.82 [1.56–4.92]

0.49 [0.30–0.76]

SAPS II (>67.5)

0.86 [0.80–0.91]

63.8 % [48.5–77.3]

91.3 % [85.3–95.4]

71.4 % [56.6–90.2]

88.1 % [81.3–90.9]

7.34 [3.30–16.80]

0.40 [0.24–0.60]

SOFA D1 (>7.5)

0.78 [0.71–0.85]

87.5 % [74.7–95.2]

55.1 % [46.4–63.7]

40.8 % [35.5–45.3]

92.6 % [74.7–100]

1.95 [1.39–2.62]

0.23 [0.07–0.54]

  1. AUROCC area under receiver operating characteristics curve, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, PCT procalcitonin, sTREM-1 soluble triggering receptor expressed on myeloid cells-1, SAPS simplified acute physiologic score, SOFA sequential organ failure assessment, ICU intensive care unit