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Table 3 Clinical performance of biomarkers and clinical scoring systems in predicting all-cause ICU mortality

From: Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis

  AUROCC [95 % CI] Se (%) [95 % CI] Sp (%) [95 % CI] PPV (%) [95 % CI] NPV (%) [95 % CI] Positive LR [95 % CI] Negative LR [95 % CI]
sTREM-1 (>954.4 ng/L) 0.64 [0.54–0.74] 54.5 % [40.5–68.0] 78.0 % [70.3–84.5] 49.2 % [40.5–54.6] 81.5 % [70.3–92.4] 2.48 [1.36–4.39] 0.58 [0.37–0.85]
PCT (>11.1 ug/L) 0.62 [0.53–0.71] 66.7 % [52.5–78.9] 55.8 % [47.1–64.2] 37.1 % [28.3–42.5] 81.0 % [67.1–91.4] 1.51 [0.99–2.20] 0.60 [0.33–1.01]
Lactate (>3.2 mmol/L) 0.71 [0.62–0.80] 61.2 % [46.2–74.8] 78.3 % [70.4–84.8] 50.0 % [37.7–61.1] 84.8 % [70.4–92.0] 2.82 [1.56–4.92] 0.49 [0.30–0.76]
SAPS II (>67.5) 0.86 [0.80–0.91] 63.8 % [48.5–77.3] 91.3 % [85.3–95.4] 71.4 % [56.6–90.2] 88.1 % [81.3–90.9] 7.34 [3.30–16.80] 0.40 [0.24–0.60]
SOFA D1 (>7.5) 0.78 [0.71–0.85] 87.5 % [74.7–95.2] 55.1 % [46.4–63.7] 40.8 % [35.5–45.3] 92.6 % [74.7–100] 1.95 [1.39–2.62] 0.23 [0.07–0.54]
  1. AUROCC area under receiver operating characteristics curve, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, PCT procalcitonin, sTREM-1 soluble triggering receptor expressed on myeloid cells-1, SAPS simplified acute physiologic score, SOFA sequential organ failure assessment, ICU intensive care unit