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Table 3 Epidemiological and clinical differences between children with (VIKIA+) and without rotavirus. Univariate and Multivariate analysis

From: Multicenter prospective study on the burden of rotavirus gastroenteritis in children less than 3 years of age in Spain

   Univariate analysis Multivariate analysis (N = 375)
   N OR IC 95 % p-value OR CI 95 % p-value
Gender Male 453    0.080    
Female 1.395 0.961–2.023 0.080    
Age (months) 454 0.978 0.957–0.999 0.038 0.984 0.958–1.010 0.215
RV Vaccination Complete vaccination 444    <0.001    <0.001
Partial vaccination 0.685 0.143–3.278 0.636 0.751 0.144–3.919 0.735
No vaccination 5.649 3.316–9.625 <0.001 5.758 3.196–10.374 <0.001
Breastfeeding No 452    0.138    
Yes 1.467 0.884–2.435 0.138    
Attendance at day care centre No 449    0.021    
Yes 0.641 0.440–0.934 0.021    
Fever 24 h. befote the visit No 453    <0.001    0.018
Yes 2.208 1.512–3.223 <0.001 1.779 1.103–2.868 0.018
Number of episodes of vomiting 24 h. before the visit 423 1.246 1.138–1.363 <0.001 1.112 1.000–1.236 0.050
Number of depositions 24 h. before the visit 448 1.004 0.953–1.059 0.873    
Dehydration 24 h. before the visit No 448    <0.001    
Yes 3.111 1.737–5.569 <0.001    
Rehydratation treatment 24 h. before the visit No 419    0.004    0.170
Yes 1.806 1.209–2.698 0.004 1.413 0.862–2.316 0.170
Fever returning at the follow-up No 412    0.037    
Yes 1.520 1.026–2.252 0.037    
Number of daily episodes of vomiting during the follow-up 446 1.219 1.111–1.338 <0.001    
Maximum number of daily depositions during the follow-up 454 1.085 1.024–1.149 0.005    
Grade of dehydration during the follow-up A 322    0.110    
B 8.207 0.998–67.456 0.050    
C 1.565 0.530–4.621 0.417    
Hospitalization No 449    0.108    
Yes 2.094 0.850–5.157 0.108    
Visits general practitioner/paediatrician No 429    0.347    
Yes 1.466 0.660–3.255 0.347    
Visits to emergency department No 358    <0.001    
Yes 2.134 1.361–3.345 <0.001    
Phone consultations No 337    0.231    
Yes 1.335 0.832–2.142 0.231    
Child´s behaviour: Cries more No 449    <0.001    
Yes 2.621 1.756–3.912 <0.001    
Child´s behaviour: is more irritable No 449    <0.001    
Yes 2.184 1.445–3.303 <0.001    
Child´s behaviour: Plays less No 446    <0.001    
Yes 2.702 1.816–4.019 <0.001    
Child´s behaviour: Is more tired No 449    <0.001    0.002
Yes 2.909 1.921–4.405 <0.001 2.277 1.357–3.819 0.002
Impact on the parents: worried because of the symptoms No 451    0.092    
Yes 3.038 0.836–11.040 0.092    
Impact on the parents: Sleep disturbance No 451    0.043    
Yes 1.824 1.020–3.262 0.043    
Impact on the parents: Need of external aid No 448    0.002    
Yes 1.839 1.246–2.715 0.002    
Impact on the parents: Alteration of the working rhythm No 449    <0.001    0.264
Yes 2.154 1.429–3.245 <0.001 1.351 0.797–2.290 0.264
Impact on the parents: Loss of working days No 451    0.076    
Yes 1.508 0.958–2.376 0.076    
  1. OR Odds Ratio, CI 95 % 95 % Confidence interval
  2. Dependent variable of logistic regression: Result of the VIKIA test for RV (Positive = 1/Negative = 0)