Preparation | N mice | Day 0 1st dose | Preparation | Day 7 2nd dose | Day 14 3d dose | Day 21b | Day 42 N mice | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
ELISA | PRNT50 TBEV Vas | PRNT50 TBEV Abs | PRNT50 TBEV Sof | Survived | Healthy | ||||||
Standard scheme | |||||||||||
3DIII + AD | 10 | +a | 3DIII + AD | + | + | 1:4000 | <1:10 | 1:50 | <1:10 | 5c | 0 |
Prime-boost scheme | |||||||||||
Tick-E-Vac | 10 | + | 3DIII + AD | + | + | 1:3000 | 1:20 | 1:250 | 1:50 | 10c | 6 |
Reference scheme | |||||||||||
Tick-E-Vac | 10 | – | Tick-E-Vac | + | + | 1:1500 | 1:80 | 1:100 | 1:250 | 10c | 10 |
Control | |||||||||||
Saline | 10 | + | Saline | + | + | <1:500 | <1:10 | <1:10 | <1:10 | 0 | 0 |