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Table 1 Number of serum samples with antibody-dependent enhancement (ADE) activitya to each of the 4 dengue virus (DENV) serotypes, pre- and post-Japanese encephalitis (JE) vaccination

From: Japanese encephalitis vaccine-facilitated dengue virus infection-enhancement antibody in adults

Samples

Number of serum samples that demonstrated ADE activity (Percentage of samples with ADE activity)

DENV-1

DENV-2

DENV-3

DENV-4

Pre-JE vaccination

(n = 77)

5 (6 %)

2 (3 %)

11 (14 %)

10 (13 %)

Post-JE vaccination

(n = 77)

14 (18 %)

16 (21 %)

24 (31 %)

24 (31 %)

  1. aThe number of serum samples observed with ADE activity to each of the four DENV serotypes significantly increased after JE vaccination (Fisher’s exact test): DENV-1 (p = 0.03), DENV-2 (p < 0.01), DENV-3 (p < 0.01), and DENV-4 (p < 0.01)