Does cemented or cementless single-stage exchange arthroplasty of chronic periprosthetic hip infections provide similar infection rates to a two-stage? A systematic review

George, D. A.; Logoluso, N.; Castellini, G.; Gianola, S.; Scarponi, S.; Haddad, F. S.; Drago, L.; Romano, C. L.

doi:10.1186/s12879-016-1869-4

Table 1 General characteristics, record bias and reporting bias of included studies

From: Does cemented or cementless single-stage exchange arthroplasty of chronic periprosthetic hip infections provide similar infection rates to a two-stage? A systematic review

Study First Author	Ref.	Year	Patients (n)	Stage Investigated	Follow Up (months)			Design	Record Bias	Reporting Bias (Outcome Measure)
Study First Author	Ref.	Year	Patients (n)	Stage Investigated	Min	Max	Mean	Design	Record Bias	Reporting Bias (Outcome Measure)
Babiak	[28]	2012	9	Two	36	180	84	NA	Yes	NA
Babis	[29]	2015	31	Two	20	48	30	Retrospective	Yes	Symptoms, Imaging, Laboratory
Berend	[30]	2013	186	Two	24	180	53	Retrospective	NR	Culture
Biring	[31]	2009	48	Two	120	180	144	Retrospective	Yes	Culture
Bori	[32]	2014	24	Single	25	94	45	Retrospective	Yes	Culture
Buchholz	[33]	1981	583	Single	24	132	–	Prospective	Yes	Culture
Buttaro	[34]	2005	29	Two	24	60	32.4	Retrospective	Yes	Symptoms, Imaging, Laboratory
Cabrita	[8]	2007	38	Two	24	102	48	Prospective	Yes	Culture
Callaghan	[35]	1999	12	Single	12	168	109.2	Retrospective	Yes	Imaging
Camurcu	[36]	2015	41	Two	24	96	54	Retrospective	Yes	Culture
Carlsson	[37]	1985	72	Both	12	72	–	Prospective	Yes	Symptoms, Imaging, Culture
Chen	[38]	2015	155	Two	36	180	116.4	Retrospective	NR	Culture
Choi	[12]	2013	61	Both	12	132	61	Retrospective	Yes	Culture
Colyer	[10]	1994	37	Two	12	88	36	Unclear	Yes	Culture
Cordero-Ampuero	[39]	2009	36	Two	12	144	52.8	Prospective	Yes	Culture
D'Angelo	[40]	2011	28	Two	18	106	53	Retrospective	Yes	Symptoms, Imaging, Laboratory
Darley	[41]	2009	19	Two	24	36	26	Prospective	Yes	Symptoms, Culture
De Man	[42]	2011	72	Both	17	204	60	Retrospective	Yes	Culture
Degen	[43]	2012	30	Two	24	70	43	Retrospective	Yes	Symptoms, Culture
Ekpo	[44]	2014	19	Two	24	132	48	Retrospective	Yes	Laboratory, Culture
Evans	[45]	2004	23	Two	24	108	48	Prospective	NR	Symptoms, Culture
Fehring	[46]	1999	25	Two	24	98	41	Prospective	Yes	Symptoms, Laboratory
Fink	[47]	2009	36	Two	24	60	35	Prospective	Yes	Culture
Fitzgerald	[48]	1985	131	Two	24	108	49	Retrospective	Yes	Symptoms
Gao	[49]	2008	15	Both	12	37	19	NA	NA	Culture
Garvin	[50]	1994	40	Both	24	120	60	NA	NA	Culture
Haddad	[51]	2000	50	Two	24	104	69.6	Retrospective	Yes	Symptoms
Hofmann	[52]	2005	27	Two	28	148	76	Retrospective	Yes	Symptoms, Imaging, Laboratory
Hope	[53]	1989	80	Both	2	121	–	Retrospective	Yes	Culture
Hsieh	[55]	2004	128	Two	24	96	58.8	Retrospective	Yes	Symptoms, Laboratory
Hsieh	[11]	2009	99	Two	24	60	43	Retrospective	Yes	Symptoms, Culture
Hsieh	[54]	2013	28	Two	48	120	86	Retrospective	Yes	Symptoms,Culture, Laboratory
Hughes	[24]	1979	26	Both	32	83	51	Retrospective	Yes	Symptoms, Imaging, Laboratory, Culture
Ibrahim	[56]	2014	125	Two	60	75	103.2	Retrospective	Yes	Symptoms, Laboratory, Culture
Ilchmann	[57]	2015	38	Single	24	181.2	79.2	Retrospective	Yes	Symptoms, Culture
Jenny	[58]	2014	63	Single	36	72	–	Retrospective	Yes	Symptoms, Culture
Johnson	[59]	2013	66	Two	24	105	45	Retrospective	Yes	Symptoms, Laboratory, Culture
Karpas	[60]	2003	18	Two	24	120	42	Retrospective	Yes	NR
Kent	[61]	2010	12	Two	26	60	38	Retrospective	NR	NR
Ketterl	[13]	1988	161	Two	24	168	32	NA	NA	NA
Kim	[63]	2011	130	Two	60	168	124.8	Retrospective	Yes	Laboratory, Culture
Klouche	[22]	2012	84	Both	24	68	35	Prospective	Yes	Culture
Koo	[62]	2001	22	Two	24	78	41	Prospective	Yes	Symptoms, Imaging, Laboratory
Lai	[64]	1996	39	Two	30	84	48	Prospective	Yes	Symptoms, Laboratory
Lee	[65]	2013	17	Two	24	96	48	Retrospective	Yes	Symptoms, Laboratory, Culture
Leung	[66]	2011	38	Two	24	123	58	Retrospective	Yes	Symptoms,Laboratory
Li	[67]	2015	10	Both	78	187.2	103.2	Retrospective	Yes	Symptoms, Laboratory, Culture
Lieberman	[68]	1994	32	Two	24	74	40	Retrospective	NR	NR
Macheras	[69]	2012	35	Two	84	168	139.2	Retrospective	Yes	NR
Magnan	[70]	2001	8	Two	24	48	35	Retrospective	NR	NR
Masri	[71]	2007	29	Two	24	88	47	Retrospective	Yes	Symptoms, Laboratory
McDonald	[72]	1989	81	Two	24	163.2	66	Prospective	Yes	Culture
McKenna	[73]	2009	30	Two	24	60	35	Retrospective	Yes	Laboratory
Miley	[74]	1982	46	Single	32	–	48.5	Prospective	NR	Unclear
Morales	[75]	1999	37	Two	36	156	57.6	NA	NA	NA
Morscher	[76]	1994	74	Both	12	132	84	NA	Yes	Symptoms, Imaging, Laboratory
Mulcahy	[77]	1996	15	Single	24	84	53	Retrospective	Yes	Symptoms, Imaging, Laboratory, Culture
Nestor	[78]	1994	34	Two	24	72	47	Retrospective	Yes	Culture
Neumann	[79]	2011	44	Two	36	120	67	Retrospective	Yes	Laboratory
Nusem	[80]	2006	18	Two	60	168	108	Retrospective	Yes	Unclear
Oussedik	[9]	2010	50	Both	66	105.7	81.6	Prospective	Yes	Imaging, Laboratory
Pignatti	[81]	2010	41	Two	60	120	63.6	Retrospective	Yes	Symptoms, Imaging, Laboratory
Raut	[82]	1995	57	Single	24	151	88	Prospective	Yes	Symptoms, Laboratory
Romanò	[83]	2012	183	Two	24	104	56	Retrospective	Yes	Laboratory, Culture
Rudelli	[84]	2008	32	Single	24	96	52.8	Unclear	Yes	Imaging, Laboratory, Culture
Sabry	[85]	2013	78	Two	24.3	135.3	58	Retrospective	Yes	Symptoms, Laboratory
Sanchez	[86]	2009	168	Two	24	192	84	Retrospective	Yes	Symptoms, Culture
Sanzen	[87]	1988	102	Both	24	108	–	Prospective	Yes	Culture
Schneider	[88]	1989	26	Single	12	108	–	NA	Yes	NA
Schwarzkopf	[89]	2014	56	Two	12	–	32.4	Retrospective	Yes	Laboratory, Culture
Seung-Jae	[90]	2009	34	Two	24	120	52.8	Retrospective	Yes	Symptoms, Culture
Stockley	[91]	2008	114	Two	24	175	74	Prospective	Yes	Symptoms, Laboratory, Culture
Sudo	[25]	2008	7	Two	27.6	73.2	60	Retrospective	Yes	Symptoms, Imaging, Laboratory
Takigami	[92]	2010	8	Two	24	81	49	Retrospective	Yes	Symptoms, Laboratory
Thabe	[93]	2007	16	Two	72	120	75.6	Prospective	Yes	NR
Toulson	[94]	2009	82	Two	24	203	64.8	Retrospective	Yes	Unclear
Ure	[95]	1998	20	Single	42	205.2	118.8	Prospective	Yes	Symptoms, Imaging, Laboratory, Culture
van Diemen	[96]	2013	136	Two	24	180	72	Retrospective	Yes	Symptoms, Imaging, Laboratory, Culture
Wang	[97]	2011	12	Two	36	96	64.8	NA	Yes	NR
Weber	[98]	1986	33	Both	60	96	72	Retrospective	NR	Laboratory
Whittaker	[99]	2009	41	Two	25	83	49	Retrospective	Yes	Culture, Laboratory
Wilson	[100]	1974	19	Single	24	–	–	Prospective		Culture
Wilson	[24]	1989	22	Both	36	120	60.2	Prospective	Yes	Symptoms, Imaging, Laboratory
Winkler	[27]	2008	37	Single	63	183	103	Prospective	Yes	Symptoms, Imaging, Laboratory
Wolf	[101]	2014	92	Both	24	–	–	Retrospective	Yes	Symptoms, Laboratory, Culture
Wroblewski	[23]	1986	101	Single	38.8	–	–	Prospective	NR	NR
Yamamoto	[102]	2003	17	Two	14	62	38	Retrospective	Yes	Laboratory
Yoo	[103]	2009	12	Single	39.6	135.6	86.4	Prospective	Yes	Laboratory, Culture
Younger	[104]	1997	48	Two	24	63	43	Prospective	Yes	Culture
Zeller	[105]	2014	99	Single	24	–	41.6	Prospective	Yes	NA

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