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Table 1 Characteristics of dengue patients by disease severity during outbreak in central Brazil

From: High frequency of pre-existing neutralizing antibody responses in patients with dengue during an outbreak in Central Brazil

Characteristics Severe denguea n = 40 Dengue n = 20 p b
Age, mean SD, years 33.6 ± 18.5 47.05 ± 20.5 <0.001
Sex, ratio of females to males 2.1:1.0 0.8:1.0  
Educational level, yearsc(%)
  ≤ 8 17(51.5) 7(41.2) 0.49
  > 8 16(48.5) 10(58.8)  
Raced, (%)
 White 18(48.7) 7(36.8) 0.46
 Mixed/Black 19(51.3) 12(63.2)  
Hospitalization, (%) 20(50.0) 3(15.0) <0.01
Hemorrhagic manifestation, (%) 36(90.0) 6e(30.0) <0.01
Platelet count nadir, platelets/mm3f
  > 100 16(40.0) 15(75.0) 0.02
  > 50 to ≤ 100 18(45.0) 5(25.0)  
  ≤ 50 6(15.0) -  
Hematocrit increase, (%)
  < 10 32(80.0) 13(65.0) 0.35
  ≥ 10 8(20.0) 7(35.0)  
Albumin, (%)  
  < 3.5 – low values 19(47.5) 4(20.0) 0.04
 3.5–5.5 – normal values 21(52.5) 16(80.0)  
AST, (%)
  < 50 – normal values 13(32.5) 12(60.0) 0.04
  ≥ 50 – high values 27(67.5) 8(40.0)  
ALT, (%)
  < 41 – normal values 18(45.0) 11(55.0) 0.46
  ≥ 41 – high values 22(55.0) 9(45.0)  
  1. Data are the no. (%) of subjects, unless otherwise indicated; AST aspartate aminotransferase, ALT alanine aminotransferase. Platelet count nadir was defined as the lowest platelet value obtained
  2. aClinically classified as dengue with warning signs or severe dengue
  3. b X 2 test was used for categorical variables
  4. cData were missing for seven severe dengue cases and three dengue cases
  5. dData were missing for three severe dengue cases and one dengue case
  6. ePositive tourniquet test as the only hemorrhagic manifestation
  7. fThe platelet count nadir was defined as the lowest platelet value obtained