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Table 2 Minimal Inhibitory Concentrations (MIC) of carbapenem non-susceptible, cephalosporin susceptible carbapenemase producing isolates

From: Antimicrobial susceptibility testing in predicting the presence of carbapenemase genes in Enterobacteriaceae in South Africa

Sample ID Organism NDM KPC OXA-48& variants IMP VIM GES Cefepime MIC Cefotaxime MIC Ceftazidime MIC Ertapenem MIC Imipenem MIC Meropenem MIC Doripenem MIC
ML0056 Klebsiella oxytoca - - + - - - 16 8 <=1 >4 >8 >8 Not tested
ML0273 Klebsiella pneumoniae - - + - - - 2 4 <=1 >1 >8 >8 >4
ML0344 Providencia rettgeri + - - + - - 8 32 >16 4 >8 4 Not tested
ML0432 Serratia marcescens - - - - - + <=1 4 2 >4 >8 >8 Not tested
ML0484 Klebsiella pneumoniae - - + - - - <=1 2 <=1 >1 >8 4 4
ML0513 Klebsiella pneumoniae - - + - - - <=1 4 <=1 >1 4 8 4
ML0514 Klebsiella pneumoniae - - + - - - <=1 2 <=1 >1 2 4 4
ML0515 Klebsiella pneumoniae - - + - - - <=1 2 <=1 >1 4 >8 >4
ML0517 Klebsiella pneumoniae - - + + - - <=1 2 <=1 >1 4 4 4
ML0634 Serratia marcescens - - + - - - 8 >32 16 >1 >8 >8 >4
ML0794 Klebsiella pneumoniae - - + - - - <=1 <=1 <=1 >1 2 2 <=1
ML0825 Serratia marcescens - - + - - - 8 >32 16 >1 >8 >8 >4
ML0841 Serratia marcescens - - - - - + 8 32 8 >1 >8 >8 >4
ML0878 Providencia rettgeri + - - - - - 8 32 >16 >1 >8 >8 >4
ML0883 Serratia marcescens - - + - - - 8 >32 16 >1 8 >8 >4
ML0886 Serratia marcescens - - + - - - 8 >32 >16 >1 >8 >8 >4
ML0905 Serratia marcescens - - + - - - 8 4 2 >1 8 >8 >4
ML0910 Enterobacter gergoviae - - + - - - 4 4 <=1 >1 2 >8 >4
ML0918 Providencia rettgeri + - - - - - 8 32 >16 >1 >8 8 >4
ML0976 Escherichia coli - - + - - - <=1 2 <=1 >1 2 4 4
ML0999 Providencia rettgeri + - - - - - 8 32 >16 >1 >8 >8 >4
ML1167 Serratia marcescens - - + - - - 8 >32 16 >1 >8 >8 >4
ML1176 Providencia rettgeri + - - - - - 8 16 >16 1 >8 8 >4
ML1411 Klebsiella pneumoniae - - + - - - 8 >32 8 >1 8 2 4
  1. CLSI breakpoints: Cefepime: <=2 – Susceptible, 4-8 – Susceptible-Dose Dependant, > = 16 – Resistant; Cefotaxime: <=1 - Susceptible, 2 – Intermediate, > = 4 – Resistant; Ceftazidime: <=4 - - Susceptible, 8 – Intermediate, > = 16 – Resistant; Ertapenem: <=0.5- Susceptible, 1 – Intermediate, > = 2 – Resistant; Imipenem/Meropenem/Doripenem: <=1 – Susceptible, 2 – Intermediate, > = 4 Resistant [34]