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Table 2 Minimal Inhibitory Concentrations (MIC) of carbapenem non-susceptible, cephalosporin susceptible carbapenemase producing isolates

From: Antimicrobial susceptibility testing in predicting the presence of carbapenemase genes in Enterobacteriaceae in South Africa

Sample ID

Organism

NDM

KPC

OXA-48& variants

IMP

VIM

GES

Cefepime MIC

Cefotaxime MIC

Ceftazidime MIC

Ertapenem MIC

Imipenem MIC

Meropenem MIC

Doripenem MIC

ML0056

Klebsiella oxytoca

-

-

+

-

-

-

16

8

<=1

>4

>8

>8

Not tested

ML0273

Klebsiella pneumoniae

-

-

+

-

-

-

2

4

<=1

>1

>8

>8

>4

ML0344

Providencia rettgeri

+

-

-

+

-

-

8

32

>16

4

>8

4

Not tested

ML0432

Serratia marcescens

-

-

-

-

-

+

<=1

4

2

>4

>8

>8

Not tested

ML0484

Klebsiella pneumoniae

-

-

+

-

-

-

<=1

2

<=1

>1

>8

4

4

ML0513

Klebsiella pneumoniae

-

-

+

-

-

-

<=1

4

<=1

>1

4

8

4

ML0514

Klebsiella pneumoniae

-

-

+

-

-

-

<=1

2

<=1

>1

2

4

4

ML0515

Klebsiella pneumoniae

-

-

+

-

-

-

<=1

2

<=1

>1

4

>8

>4

ML0517

Klebsiella pneumoniae

-

-

+

+

-

-

<=1

2

<=1

>1

4

4

4

ML0634

Serratia marcescens

-

-

+

-

-

-

8

>32

16

>1

>8

>8

>4

ML0794

Klebsiella pneumoniae

-

-

+

-

-

-

<=1

<=1

<=1

>1

2

2

<=1

ML0825

Serratia marcescens

-

-

+

-

-

-

8

>32

16

>1

>8

>8

>4

ML0841

Serratia marcescens

-

-

-

-

-

+

8

32

8

>1

>8

>8

>4

ML0878

Providencia rettgeri

+

-

-

-

-

-

8

32

>16

>1

>8

>8

>4

ML0883

Serratia marcescens

-

-

+

-

-

-

8

>32

16

>1

8

>8

>4

ML0886

Serratia marcescens

-

-

+

-

-

-

8

>32

>16

>1

>8

>8

>4

ML0905

Serratia marcescens

-

-

+

-

-

-

8

4

2

>1

8

>8

>4

ML0910

Enterobacter gergoviae

-

-

+

-

-

-

4

4

<=1

>1

2

>8

>4

ML0918

Providencia rettgeri

+

-

-

-

-

-

8

32

>16

>1

>8

8

>4

ML0976

Escherichia coli

-

-

+

-

-

-

<=1

2

<=1

>1

2

4

4

ML0999

Providencia rettgeri

+

-

-

-

-

-

8

32

>16

>1

>8

>8

>4

ML1167

Serratia marcescens

-

-

+

-

-

-

8

>32

16

>1

>8

>8

>4

ML1176

Providencia rettgeri

+

-

-

-

-

-

8

16

>16

1

>8

8

>4

ML1411

Klebsiella pneumoniae

-

-

+

-

-

-

8

>32

8

>1

8

2

4

  1. CLSI breakpoints: Cefepime: <=2 – Susceptible, 4-8 – Susceptible-Dose Dependant, > = 16 – Resistant; Cefotaxime: <=1 - Susceptible, 2 – Intermediate, > = 4 – Resistant; Ceftazidime: <=4 - - Susceptible, 8 – Intermediate, > = 16 – Resistant; Ertapenem: <=0.5- Susceptible, 1 – Intermediate, > = 2 – Resistant; Imipenem/Meropenem/Doripenem: <=1 – Susceptible, 2 – Intermediate, > = 4 Resistant [34]