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Table 1 Minimal inhibitory concentrations (MIC) of ertapenem susceptible carbapenemase producing isolates

From: Antimicrobial susceptibility testing in predicting the presence of carbapenemase genes in Enterobacteriaceae in South Africa

Sample ID

ORGANISM

NDM

KPC

OXA-48 & variants

IMP

VIM

GES

Cefepime MIC

Cefotaxime MIC

Ceftazidime MIC

Ertapenem MIC

Imipenem MIC

Meropenem MIC

Doripenem MIC

ML0148.2

Enterobacter cloacae

-

-

-

+

-

-

>16

>32

>16

<=0.5

<=2

<=1

Not tested

ML0191

Klebsiella pneumoniae

-

-

-

-

-

+

8

>32

>16

<=0.5

<=2

<=1

Not tested

ML0440

Klebsiella pneumoniae

-

-

-

-

+

-

16

>32

>16

<=0.5

4

2

Not tested

ML0446

Klebsiella pneumoniae

-

-

-

-

+

-

<=1

<=1

<=1

<=0.5

<=2

<=1

Not tested

ML0848

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

4

<=1

<=1

ML0917

Providencia rettgeri

+

-

-

-

-

-

<=1

<=1

<=1

<=0.5

<=1

<=1

<=1

ML0926

Escherichia coli

+

-

-

-

-

-

<=1

<=1

<=1

<=0.5

<=1

<=1

<=1

ML0930

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

4

<=1

<=1

ML1002

Providencia rettgeri

+

-

-

-

-

-

8

32

>16

<=0.5

>8

2

2

ML1007

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

4

<=1

2

ML1161

Klebsiella pneumoniae

-

-

+

-

-

-

>16

>32

>16

<=0.5

<=2

<=1

Not tested

ML1187

Escherichia coli

-

-

+

-

+

-

2

8

16

<=0.5

4

<=1

<=1

ML1189

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

2

<=1

<=1

ML1219

Klebsiella pneumoniae

-

-

-

-

+

-

16

>32

>16

<=0.5

2

<=1

<=1

ML1279

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

2

<=1

<=1

ML1296

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

4

<=1

<=1

ML1340

Morganella morganii

+

-

-

-

-

-

8

>32

>16

<=0.5

8

<=1

2

ML1354

Klebsiella pneumoniae

-

-

-

-

+

-

>16

>32

>16

<=0.5

4

<=1

2

  1. CLSI breakpoints: Cefepime: <=2 – Susceptible, 4-8 – Susceptible-Dose Dependant, > = 16 – Resistant; Cefotaxime: <=1 - Susceptible, 2 – Intermediate, > = 4 – Resistant; Ceftazidime: <=4 - - Susceptible, 8 – Intermediate, > = 16 – Resistant; Ertapenem: <=0.5- Susceptible, 1 – Intermediate, > = 2 – Resistant; Imipenem/Meropenem/Doripenem: <=1 – Susceptible, 2 – Intermediate, > = 4 Resistant [34]
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BMC Infectious Diseases

ISSN: 1471-2334

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