Is Hepatitis Delta infections important in Brazil?

BMC Infectious Diseases

Table 3 Codon-based analysis of d_N/d_S rates in the L-HDAg gene of Hepatitis Delta virus

Model	p	-nlL	Estimated parameters	Sites^b
Site-specific models for HDV-3 (n = 47)
M7 (beta)	2	5471.30397	p = 0.09695 q = 0.15394 k (ts/tv) = 3.53356	Not allowed
M8 (beta&ω)^a	4	5293.55296	p ₀ = 0.82801 p = 0.11508 q = 0.24197 (p ₁ = 0.17199) ω = 5.03937 k (ts/tv) = 4.64237	4P, 8 K, 9 K, 29E, 37 T, 44 L, 54I, 55 V, 63D, 73P, 77A, 80I, 82S, 84P, 96Q, 120S, 123Q, 130G, 134 K, 143 V, 169 N, 190 T, 198 F, 205H
Site-specific models for the others HDV Genotypes (n = 78)
M7 (beta)	2	9893.49320	p = 0.27034 q = 0.48352 k (ts/tv) = 2.60287	Not allowed
M8 (beta&ω)^a	4	9781.56864	p ₀ = 0.92957 p = 0.31395 q = 0.63880 (p ₁ = 0.07043) ω = 3.27612 k (ts/tv) = 2.85894	6 L, 8 K, 9 K, 16I, 37 T, 120S, 157G, 179A, 187I

InL Maximun likelihood of each model
^a Best-fit model according to the LRT comparing the M7 and M8 models, using two degrees of freedom and a significance level of 0.010
^b Positive selected codons were identified according to the Bayes Empirical Bayes (BEB) analysis with P > 99 %

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