Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors

BMC Infectious Diseases

Table 6 Cox proportional hazards model predicting time to resolution of TB-IRIS symptoms excluding Brooklyn Chest Hospital cohort (Cohort 2)

	Adjusted HR (95 % CI)	p-value
Age (per 1 year increase)	0.99 (0.96–1.01)	0.36
Male gender	1.42 (0.92–2.18)	0.11
Lymph node involvement at initial TB diagnosis	0.72 (0.44–1.17)	0.18
Drug-resistant TB	0.65 (0.36–1.20)	0.17
Hospitalised at time of TB-IRIS diagnosis	0.93 (0.62–1.40)	0.73
TB-IRIS pulmonary involvement	1.23 (0.82–1.83)	0.32
TB-IRIS lymph node involvement	0.60 (0.40–0.89)	0.01

In the Cox proportional hazards model, even when the Brooklyn Chest Hospital cohort (Cohort 2) was excluded, TB-IRIS lymph node involvement remained statistically significantly associated with a lower hazard of TB-IRIS resolution (aHR 0.60, 95 % CI 0.40–0.89; p = 0.01)

ISSN: 1471-2334