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Table 4 Odds ratios for univariate (unadjusted) and multivariate (adjusted) logistic regression models predicting the development of prolonged TB-IRIS (n = 181)

From: Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors

  Unadjusted OR (95 % CI) Unadjusted p-value Adjusted OR (95 % CI) Adjusted p-value
Age (per 1 year increase) 0.97 (0.93–1.01) 0.16 0.98 (0.94–1.05) 0.48
Male gender 0.72 (0.38–1.35) 0.31 0.80 (0.39–1.63) 0.54
Lymph node involvement at initial TB diagnosis 2.36 (1.18–4.76) 0.02 1.79 (0.81–3.98) 0.15
Drug-resistant TBa 4.13 (1.32–15.56) 0.02 3.26 (0.97–12.99) 0.07
Hospitalised at time of TB-IRIS diagnosis 0.40 (0.22–0.75) 0.004 0.5 (0.25–0.99) 0.05
TB-IRIS lymph node involvement 3.01 (1.63–5.65) 0.0005 2.27 (1.13–4.59) 0.02
TB-IRIS pulmonary involvement 0.54 (0.29–1.02) 0.06 0.65 (0.32–1.30) 0.23
Cohort 2b 0.06 (0.01–0.18) < 0.0001 Not included  
Cohort 1b 0.29 (0.12–0.62) 0.002 Not included  
  1. Abbreviations: IRIS immune reconstitution inflammatory syndrome, TB tuberculosis
  2. aThe reference group is combined culture negative, culture not done and drug susceptible
  3. bReference cohort was randomized controlled trial