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Table 5 The resistance of Mtb isolated in China to first-line drugs and FQsa

From: Persistently high prevalence of primary resistance and multidrug resistance of tuberculosis in Heilongjiang Province, China

Location (Ref.) Sampling
Year
Sampling sourceb Sample
size
First-line Resistance (%) MDR rate (%) FQ Resistance (%)c
Total New Total New Total MDR
China [1, 27, 28] 2007 Survey 3929 38.3 34.2 10.2 5.7   
  2007–2008 Survey 3634    9.9   4.0  
  2005–2012 Hospital 450 54.4 44.7 25.8 14.5   
Jilin [29] 2008–2011 Survey 1772 40.1 33.1 13.5 8.60   
Ningxia [30] 2013–2014 Survey 665 26.6 20.2 7.8    
Chongqing [31] 2009–2013 Hospital 2271 61.9 52.9 26.3 16.7   
Lianyungang, Jiangsu [32] 2011–2012 Survey 1012 30.4 23.4 8.7 4.2   
Kaohsiung, Taiwan [33] 2000–2008 Hospital 421 15.2   2.1    
Beijing [34] 2007–2009 Hospital 967 70.1 60.9 19.4 14.9 27.1 35.1
Xinjiang [35, 36] 2009–2013 Hospital 410    13.2 12.9   
Heilongjiang (present) 2007–2012 Hospital 1427 57.0 48.7 22.8 13.6   
  2007–2009 Hospital 821 61.9 60.0 26.2 16.5   
  2010–2012 Hospital 606 50.5 41.9 18.2 9.9 10.4 25.0
Kunming, Yunnan [37] 2008–2009 CDC 279 31.5   9.3    
Hunan [38] 2009–2010 Hospital 171 40.9 19.6 25.2 6.2 10.5  
Xuzhou, Jiangsu [39] 2011–2012 Hospital 287 16.0   3.14    
Zhejiang [40] 2011–2012 Hospital 1363    16.7    
Rural China [10] 2008 Hospital 380 31.1 25.9 11.3 9.0 10.8 23.3
Jiangxi [41] 2010–2011 Hospital 804    19.8    
Northeast China [42] 2010–2011 Hospital 205 26.3 22.0 6.8 3.0   
Anhui [43] 2010–2011 Hospital 420 29.1 17.1 14.5 6.8 13.3 14.8
Shenzhen [44] 2009 Hospital 589 38.0   9.3   6.8 47.3
Chongqing [45] 2011–2013 Hospital 1976    10.5    24.5
Fujian [46] 2010–2011 Survey 1389    5.4   2.3 25.3
  1. a Mtb M. tuberculosis, MDR multidrug resistance, CDC Chinese Centre for Disease Control and Prevention, FQs fluoroquinolones
  2. bData was derived based on sampling sources of hospital (Hospital), local TB control system (CDC) or nationwide random survey
  3. cThe data presented the resistance rate of FQ-resistant from total or from MDR Mtb isolates examined (resistant to Ofloxacin, in Italian; resistant to levofloxacin, underlined)