Prevalence of hepatitis B surface antigen (HBsAg) in a blood donor population born prior to and after implementation of universal HBV vaccination in Shenzhen, China

Table 5 Yield of HBsAg-/HBV DNA+ in blood donors^a

Category	OBI	WPI	Unclassified	Overall
Samples	106	11	27	144
Yield	1/4486	1/43,231	1/17,613	1/3302
Gender (F/M)	29/77	5/6	7/20	41/103
Age range (median)	20–56 (34)	19–42 (28)	19–54 (28.5)	19–56 (32)
VL range (median, IU/ml)	0–2122 (23.1)	0–7321 (190.4)	0–2782 (36.4)	0–7321 (27.9)
Anti-HBc+/anti-HBs+/anti-HBe + (%)	2	0	0	2
Anti-HBc+/anti-HBs + (%)	34	0	0	34
Anti-HBc+/anti-HBe + (%)	4	3	0	7
Anti-HBc + only (%)	54	1	0	55
Anti-HBs + only (%)	8	0	0	8
HBeAg + only (%)	0	1	0	1
Anti-HBe + only (%)	0	0	0	0
No seromarker (%)	4 (primary OBI)	6	27	37

^aHBV DNA was detected by the NAT from 475,538 blood donors with negative HBsAg and normal ALT level (<50U/L). HBV DNA+/HBsAg- carriers were detected 1–3 times for HBV DNA and sero-markers by the follow-up. The blood samples were detected for HBV DNA+/HBsAg- in follow-up samples were defined as OBIs, for seroconversion of HBsAg were defined as window period infections (WPIs), while no available of follow-up testing were defined as unclassified that might include false positive of HBV DNA samples

ISSN: 1471-2334