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Table 3 Baseline clinical characteristics of antiretroviral-naïve HIV+ patients initiating atazanavir-containing vs. atazanavir-free regimens

From: Risk of cardiovascular events among patients with HIV treated with atazanavir-containing regimens: a retrospective cohort study

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  ATV-Containing Regimen
N = 2,437
ATV-Free Regimen
N = 19,774
p-value ATV-Containing Regimen
N = 1,505
ATV-Free Regimen
N = 5,631
p-value
  N % N %   N % N %  
CHADS2 Scorea           
 0 2,040 83.7 % 16,382 82.8 % 0.3593 1,019 67.7 % 3,745 66.5 % 0.6718
 1 321 13.2 % 2,734 13.8 %   330 21.9 % 1,294 23.0 %  
 2 67 2.7 % 535 2.7 %   113 7.5 % 448 8.0 %  
 3–6 9 0.4 % 123 0.6 %   43 2.9 % 144 2.6 %  
Diabetes Mellitusb 115 4.7 % 961 4.9 % 0.7597 137 9.1 % 563 10.0 % 0.2996
Hypertensionb 370 15.2 % 3,256 16.5 % 0.1058 450 29.9 % 1,733 30.8 % 0.5125
Dyslipidemiab 306 12.6 % 2,473 12.5 % 0.9438 158 10.5 % 576 10.2 % 0.7600
Renal Disease 107 4.4 % 640 3.2 % 0.0029 146 9.7 % 524 9.3 % 0.6404
Tobacco Use Disorder 110 4.5 % 986 5.0 % 0.3095 347 23.1 % 1,257 22.3 % 0.5448
COPD 37 1.5 % 279 1.4 % 0.6730 88 5.8 % 392 7.0 % 0.1253
Anemia 186 7.6 % 1,710 8.6 % 0.0905 283 18.8 % 1,088 19.3 % 0.6507
Hepatitis C 67 2.7 % 419 2.1 % 0.0448 173 11.5 % 595 10.6 % 0.3018
Alcohol Abuse Disorder 14 0.6 % 147 0.7 % 0.3536 90 6.0 % 246 4.4 % 0.0088
Drug Abuse Disorder 137 5.6 % 1,250 6.3 % 0.1780 488 32.4 % 1,666 29.6 % 0.0331
Autoimmune/Inflammatory Disorders 86 3.5 % 731 3.7 % 0.6779 80 5.3 % 284 5.0 % 0.6700
Circulatory Disease 504 20.7 % 4,470 22.6 % 0.0316 570 37.9 % 2,178 38.7 % 0.5686
Oral Contraceptives 25 1.0 % 146 0.7 % 0.1255 13 0.9 % 42 0.7 % 0.6422
  1. COPD chronic obstructive pulmonary disorder, ATV atazanavir, SD standard deviation
  2. aCHADS2 is based on the presence of diagnoses of congestive heart failure, hypertension, diabetes, and stroke or transient ischemic attack and age ≥ 75 [11, 12]; bBoth diagnoses and medication use were evaluated