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Table 1 Studies included in this meta-analysis

From: The diagnostic value of cerebrospinal fluid lactate for post-neurosurgical bacterial meningitis: a meta-analysis

Authors Publication year Type of study Cut-off value (mmol/L) Gold standard
Leib et al. [6] 1999 Retrospective 4.0 1) or 2) or 3):
1) positive bacterial CSF culture and CSF WBC > 2.5 × 108/L
2) CSF WBC > 1 × 109/L and neutrophils >50 %
3) CSF WBC > 2.5 × 108/L and neutrophils >50 % in patients treated with steroids or antibiotics at the time of LP
Tavares et al. [25] 2006 Prospective 5.4 positive bacterial CSF culture or Gram stain
Grille et al. [21] 2012 Prospective 5.2 1) or 2):
1) positive bacterial CSF culture or Gram stain
2) negative bacterial CSF culture or Gram stain and CSF WBC > 1 × 109/L (>50 % neutrophils) in patients treated with antibiotics at the time of lumbar puncture
Maskin et al. [22] 2013 Prospective 4.0 1) or 2):
1) positive bacterial CSF culture or Gram stain and CSF WBC ≥ 1 × 105/L or (CSF glucose <40 mg/dL or CSF glucose/blood glucose <0.4)
2) CSF WBC ≥ 2.5 × 105/L and CSF glucose/blood glucose <0.5 if patients received antibiotics 24 h prior to CSF sampling
Li et al. [18] 2014 Retrospective 3.45 a All of the below:
1) clinical symptoms
2) positive bacterial CSF culture or Gram stain
3) CSF WBC count ≥1 × 109/L and polykaryocyte percentage ≥75 %
4) CSF glucose <2.5 mmol/L or CSF glucose/blood glucose <0.4.
  1. a Patients who did not meet these criteria with a CSF WBC count <5 × 108/L were classified into the non-PNBM group