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Table 4 Multivariate analysis of factors associated with development of PR: results from conditional logistic regression model

From: Determinants of treatment-related paradoxical reactions during anti-tuberculosis therapy: a case control study

Variable Odds ratio (95 % CI) P value
Age   0.98 (0.95–1.02) per increasing year 0.409
Sex   0.57 (0.19–1.67) for females 0.302
Site Chest 1.00
Abdominal 8.11 (0.18–356.01)
Brain 2.22 (0.22–23.30)
Peripheral lymph nodes 64.33 (9.60–431.25)
Other or mixed sites 1.23 (0.41–3.74) <0.001
HIV Status Negative 1.00
Positive 5.05 (1.28–19.85)
Not recorded 0.50 (0.02–14.97) 0.028
Immunosuppression No 1.00
Yes 0.01 (0.00–0.27)
Not recorded 0.13 (0.00–0.90) 0.002
Tobacco use No 1.00
Yes 0.71 (0.17–2.85)
Not recorded 3.36 (0.39–21.04) 0.462
Alcohol use No 1.00
Yes 0.21 (0.04–1.01)
Not recorded 0.01 (0.01–0.56) 0.009
ESRa Mean (mm/h) Could not fit within model
TB Diagnosis % NAAT negative 1.00
% NAAT positive 1.23 (0.11–12.63)
% NAAT not performed 0.10 (0.01–1.11) 0.009
% culture negative 1.00
% culture positive 6.87 (1.31–36.04)
% culture not performed 3.81 (0.66–22.14) 0.045
  1. aESR was only performed on a limited number of patients (n = 139, only 97 of which could be used for case control analysis): it was unable to be included in the model due to small numbers. In univariate analysis a 1-log increase in ESR was associated with a 4.43 increased odds of developing PR (95 % CI 1.30–15.1); this increased to 4.78 (1.29–17.72) when adjusted for HIV status