Variable (N = 234 total unless otherwise stated) | PR (%) (N = 82) | Matched control without PR (N = 152) | P value* | |
---|---|---|---|---|
Demographicsa | ||||
 Age (Mean) |  | 33.7 | 37.0 | 0.162 |
 Sex (%) | Male | 72 (45 %) | 72 (47 %) | – |
Female | 45 (55Â %) | 80 (53Â %) | 0.770 | |
 Ethnicity (%) | White | 8 (10 %) | 26 (17 %) | – |
Black | 32 (39 %) | 65 (43 %) | – | |
East Asian | 6 (7 %) | 9 (6 %) | – | |
South Asian | 33 (40 %) | 46 (30 %) | – | |
Other | 3 (4Â %) | 6 (4Â %) | 0.663 | |
Baseline TB disease site, symptoms & microbiology | ||||
 Site (%) | Chest b | 29 (35 %) | 96 (63 %) | – |
Abdominal | 2 (2 %) | 4 (3 %) | – | |
Brain | 2 (2 %) | 5 (3 %) | – | |
Peripheral lymph nodes | 34 (41 %) | 4 (3 %) | – | |
Other or mixed sites | 15 (18Â %) | 43 (28Â %) | <0.001 | |
 Systemic Symptoms (%)c (with weight loss) | Yes | 23 (28 %) | 45 (30 %) | – |
No | 54 (66 %) | 101 (66 %) | – | |
Not recorded | 5 (6Â %) | 6 (4Â %) | 0.901 | |
 Systemic Symptoms (%)c (without weight loss) | Yes | 27 (33 %) | 64 (42 %) | – |
No | 50 (61 %) | 82 (54 %) | – | |
Not recorded | 5 (6Â %) | 6 (4Â %) | 0.332 | |
 Acid Fast Bacilli (%) | Negative | 47 (57 %) | 88 (58 %) | – |
Positive | 25 (30 %) | 42 (28 %) | – | |
Not performed | 10 (12Â %) | 22 (14Â %) | 0.770 | |
 M. tuberculosis NAAT (%) | Negative | 8 (10 %) | 9 (6 %) | – |
Positive | 20 (24 %) | 24 (16 %) | – | |
Not performed | 54 (66Â %) | 119 (78Â %) | 0.007 | |
 M. tuberculosis Culture (%) | Negative | 13 (16 %) | 37 (24 %) | – |
Positive | 62 (76 %) | 104 (68 %) | – | |
Not performed | 7 (9Â %) | 11 (7Â %) | 0.256 | |
Immune system functioning | ||||
 HIV status (%) | Negative | 46 (56 %) | 101 (66 %) | – |
Positive | 18 (22 %) | 25 (16 %) | – | |
Not recorded | 18 (22Â %) | 26 (17Â %) | 0.413 | |
 Drug allergies (%) | No | 34 (41 %) | 60 (39 %) | – |
Yes | 2 (2 %) | 2 (1 %) | – | |
Not recorded | 46 (56Â %) | 90 (59Â %) | 0.688 | |
 Immunosuppression (%)d | No | 80 (98 %) | 130 (8^%) | – |
Yes | 1 (1 %) | 17 (11 %) | – | |
Not recorded | 1 (1Â %) | 5 (3Â %) | 0.004 | |
Potential immune–modulating lifestyle factors | ||||
 Tobacco use (%) | No | 60 (73 %) | 97 (64 %) | – |
Yes | 10 (12 %) | 37 (24 %) | – | |
Not recorded | 12 (15Â %) | 18 (12Â %) | 0.101 | |
 Alcohol use (%) | No | 59 (72 %) | 85 (56 %) | – |
Yes | 8 (10 %) | 34 (22 %) | – | |
Not recorded | 15 (18Â %) | 33 (22Â %) | 0.007 | |
Geometric mean (range) baseline blood test resultse (units, number of patients with variable data) | ||||
 White blood cell count (cells/μL, n = 229) | 7.2 (3.1–16.1) | 7.2 (2.1–18.4) | 0.953 | |
 Lymphocyte Count (cells/μL, n = 229) | 1.6 (0.4–4.2) | 1.6 (0.3–6.5) | 0.855 | |
 Haemoglobin (g/dL, n = 230) | 11.7 (7.7–16.0) | 12.0 (7.1–17.3) | 0.285 | |
 Albumin (g/dL, n = 225) | 38 (16–77) | 37 (9–50) | 0.501 | |
 Alkaline Phosphatase (U/L, n = 225) | 134 (44–823) | 123 (14–1074) | 0.627 | |
 C-Reactive Protein (mg/L, n = 203) | 62 (1–280) | 65 (1–396) | 0.939 | |
 Erythrocyte Sedimentation Rate (mm/h, n = 139) | 56 (6–132) | 46 (2–129) | 0.017 | |
 Vitamin D Levels (ng/mL, n = 85) | 27.1 (8.6–79.4) | 30.9 (6.3–168.0) | 0.764 | |
 Lactate Dehydrogenase (U/L, n = 99) | 499 (294–1156) | 523 (246–2127) | 0.699 |