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Table 2 Studies investigating spontaneous viral clearance of HCV among HIV+ MSM

From: Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis

First author (pub. yr.)

Study period

Location

 

N

 

Recruitment method

Recruitment site

Definition of HCV clearance

Quality rating

Participants

Clearers

Proportion of clearance events

95 % CI

Bottieau (2010) [62]

2001–2009

Belgium

Consecutive sampling

Clinical setting

≥1 RNA- within 6 months

Moderate

65

7

10.8

3.2

-

18.3

Dietz (2012) [63]

Not reported

Germany

Not reported

Not reported

Methods not reported

Low

47

4

8.5

0.5

-

16.5

Fierer(2014) [64]

Not reported

United States

Not reported

Not reported

≥1 RNA- within 3 months

Moderate

41

5

12.2

2.2

-

22.2

Fletcher (2003) [65]

2002–2003

United Kingdom

Not reported

Clinical setting

≥1 RNA- result

Moderate

16

6

37.5

13.8

-

61.2

Gilleece (2005) [66]

1997–2003

United Kingdom

Not reported

Clinical setting

>1 RNA- result within 3 months

Moderate

50

12

24.0

12.2

-

35.8

Grebely (2014) [29]

1985–2010

Multiple locations

Not reported

Clinical, community-based, and correctional settings

2 consecutive RNA- results separated by at least 1 month

Moderate

11

0

—

—

Martin (2013) [67]

2004–2014

United Kingdom

Consecutive sampling

Clinical setting

2 RNA- results after 6 months

High

145

31

21.4

14.7

-

28.1

Piroth (2010) [68]

2008–2009

France

Consecutive sampling

Clinical setting

≥1 RNA-

High

53

8

15.1

5.5

-

24.7

Sasadeusz (2011) [69]

2003–2007

Not reported

Consecutive sampling

Clinical setting

2 consecutive RNA- results separated by at least 3 months

Low

61

9

14.8

5.9

-

23.7

Thomson (2011) [70]

2005–2009

United Kingdom

Not reported

Clinical setting

2 consecutive RNA- results separated by at least 3 months

Moderate

99

14

14.1

7.3

-

21.0

  1. Fixed-effect meta-analysis estimate of the prevalence of spontaneous viral clearance (9 studies): 15.2 % (95 % CI 12.3, 18.1)
  2. Random-effects meta-analysis estimate of the prevalence of spontaneous viral clearance (9 studies): 15.4 % (95 % CI 11.5, 19.3)
  3. Heterogeneity: Q = 13.29, p = 0.102; I2 = 39.8 %