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Table 2 Studies investigating spontaneous viral clearance of HCV among HIV+ MSM

From: Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis

First author (pub. yr.) Study period Location   N  
Recruitment method Recruitment site Definition of HCV clearance Quality rating Participants Clearers Proportion of clearance events 95 % CI
Bottieau (2010) [62] 2001–2009 Belgium Consecutive sampling Clinical setting ≥1 RNA- within 6 months Moderate 65 7 10.8 3.2 - 18.3
Dietz (2012) [63] Not reported Germany Not reported Not reported Methods not reported Low 47 4 8.5 0.5 - 16.5
Fierer(2014) [64] Not reported United States Not reported Not reported ≥1 RNA- within 3 months Moderate 41 5 12.2 2.2 - 22.2
Fletcher (2003) [65] 2002–2003 United Kingdom Not reported Clinical setting ≥1 RNA- result Moderate 16 6 37.5 13.8 - 61.2
Gilleece (2005) [66] 1997–2003 United Kingdom Not reported Clinical setting >1 RNA- result within 3 months Moderate 50 12 24.0 12.2 - 35.8
Grebely (2014) [29] 1985–2010 Multiple locations Not reported Clinical, community-based, and correctional settings 2 consecutive RNA- results separated by at least 1 month Moderate 11 0
Martin (2013) [67] 2004–2014 United Kingdom Consecutive sampling Clinical setting 2 RNA- results after 6 months High 145 31 21.4 14.7 - 28.1
Piroth (2010) [68] 2008–2009 France Consecutive sampling Clinical setting ≥1 RNA- High 53 8 15.1 5.5 - 24.7
Sasadeusz (2011) [69] 2003–2007 Not reported Consecutive sampling Clinical setting 2 consecutive RNA- results separated by at least 3 months Low 61 9 14.8 5.9 - 23.7
Thomson (2011) [70] 2005–2009 United Kingdom Not reported Clinical setting 2 consecutive RNA- results separated by at least 3 months Moderate 99 14 14.1 7.3 - 21.0
  1. Fixed-effect meta-analysis estimate of the prevalence of spontaneous viral clearance (9 studies): 15.2 % (95 % CI 12.3, 18.1)
  2. Random-effects meta-analysis estimate of the prevalence of spontaneous viral clearance (9 studies): 15.4 % (95 % CI 11.5, 19.3)
  3. Heterogeneity: Q = 13.29, p = 0.102; I2 = 39.8 %