Table 4 Performance of clinical decision rules at the end of calendar day 3 following admission to the critical care unit in the full validation sample
Rule | Percentage ‘high risk’ | Sensitivity (95 % CI) | Specificity (95 % CI) | PPV (95 % CI) | NPV (95 % CI) |
|---|---|---|---|---|---|
FIRE Study | |||||
F1 | 27.1 | 54.1 (36.9, 70.5) | 73.0 (72.0, 73.9) | 0.87 (0.53, 1.34) | 99.7 (99.6, 99.8) |
F2 | 15.7 | 40.5 (24.8, 57.9) | 84.5 (83.7, 85.2) | 1.13 (0.63, 1.85) | 99.7 (99.5, 99.8) |
F3 | 6.4 | 24.3 (11.8, 41.2) | 93.6 (93.1, 94.2) | 1.65 (0.76, 3.11) | 99.6 (99.5, 99.8) |
Ostrosky-Zeichner et al., 2007 [6] | |||||
OZ1 | 58.5 | 86.5 (71.2, 95.5) | 41.6 (40.5, 42.7) | 0.64 (0.44, 0.91) | 99.9 (99.7, 100) |
OZ2 | 43.4 | 81.1 (64.8, 92.0) | 56.7 (55.7, 57.8) | 0.81 (0.55, 1.16) | 99.9 (99.7, 99.9) |
OZ3 | 21.1 | 51.4 (34.4, 68.1) | 79.1 (78.2, 79.9) | 1.06 (0.64, 1.65) | 99.7 (99.6, 99.8) |
Paphitou et al., 2005 [7] | |||||
P1 | 29.0 | 43.2 (27.1, 60.5) | 71.0 (70.1, 72.0) | 0.65 (0.37, 1.05) | 99.7 (99.5, 99.8) |
P2 | 83.2 | 97.3 (85.8, 99.9) | 16.8 (16.0, 17.7) | 0.51 (0.36, 0.71) | 99.9 (99.6, 100) |
P3 | 23.3 | 43.2 (27.1, 60.5) | 76.8 (75.9, 77.7) | 0.81 (0.46, 1.31) | 99.7 (99.5, 99.8) |