Variable | NTM positive | NTM negative | p-value |
---|---|---|---|
(n = 18) | (n = 200) | ||
Age, yra | 64 (13.3) | 54.9 (15.9) | 0.02 |
Age ≥ 50 years | 15 (83.3 %) | 126 (63 %) | 0.06 |
Gender (% females)b | 78 % | 60 % | 0.2 |
BMI, kg/m2 a | 23.5 (4.8) | 24.9 (4.6) | 0.24 |
BMI ≤ 23 kg/m2 b | 11 (61.1 %) | 65 (32.5 %) | 0.034 |
Idiopathic | 5 (27.8 %) | 60 (30 %) | 0.79 |
Post-infection | 6 (33.3 %) | 72 (36 %) | |
Systemic diseases | 4 (22.2 %) | 24 (12 %) | |
Immunodeficiency | 1 (5.6 %) | 4 (2 %) | |
COPD | 2 (11.1 %) | 28 (14 %) | |
Ciliary dyskinesia | 0 | 7 (3.3 %) | |
Other | 0 | 5 (2.5 %) | |
Smoking history (pack-years)c | 22.2 (33) | 11.6 (25.6) | 0.2 |
Dyspnea (mMRC) | 1.29 (1.3) | 1.33 (1.13) | 0.8 |
Macroscopic appearance of sputum (muco-purulent or purulent)a | 7 (39 %) | 125 (62.5 %) | 0.045 |
Cystic bronchiectasisb | 4 (22 %) | 52 (26 %) | 0.7 |
Number of affected lobesa | 2.9 (1.3) | 2.6 (1.2) | 0.2 |
FVC, % predicteda | 82.5 (23) | 73.5 (24) | 0.09 |
FVC ≥ 75 % predictedb | 14 (77.8 %) | 94 (47 %) | 0.011 |
FEV1, % predicteda | 72.3 (26) | 63 (25) | 0.15 |
Chronic P. aeruginosa infectionb | 5 (28 %) | 88 (44 %) | 0.1 |
Chronic H. influenzae infectionb | 2 (11 %) | 46 (23 %) | 0.1 |
Chronic bacterial infection, other PPMsb | 2 (12 %) | 90 (45 %) | 0.05 |
Isolation of Aspergillus sppb | 7 (39 %) | 52 (26 %) | 0.2 |
Macrolides (chronic use)b | 3 (17 %) | 22 (11 %) | 0.4 |
Antibiotics (chronic use)b | 4 (22 %) | 70 (35 %) | 0.2 |
Systemic steroids (chronic use) | 1 (6 %) | 8 (4 %) | 0.6 |
Hospital admissionsc | 0.5 (0.7) | 0.7 (1.1) | 0.5 |
Exacerbationsc | 2.18 (1.7) | 3 (2.1) | 0.2 |