Epidemiology and virologic investigation of human enterovirus 71 infection in the Republic of Korea from 2007 to 2012: a nationwide cross-sectional study

Table 2 Clinical manifestationsfromcases of enterovirus71 infection in Korea between 2007 and 2012

Clinical syndrome/Year	2007		2008		2009		2010		2011		2012		Total
Clinical syndrome/Year	n	%	n	%	n	%	N	%	N	%	n	%	n	%
HFMD or herpangina	11	50.0	1	50.0	103	81.1	133	70.0	58	49.2	58	46.0	364	62.2
Without complication	11	50.0	1	50.0	70	55.1	70	36.8	10	8.5	36	28.6	198	33.8
With aseptic meningitis					33	26.0	63	33.2	42	35.6	18	14.3	156	26.7
With encephalitis or ME									6	5.1	3	2.4	9	1.5
With ADEM											1	0.8	1	0.2
Aseptic meningitis only	8	36.4			18	14.2	46	24.2	31	26.3	33	26.2	136	23.2
Encephalitis or ME only					2	1.6	6	3.2	7	5.9	4	3.2	19	3.2
Myocarditis									2	1.7			2	0.3
Sepsis					1	0.8	3	1.6	5	4.2	4	3.2	13	2.2
Others^a	3	13.6	1	50.0	3	2.4	2	1.1	15	12.7	27	21.4	51	8.7
Total	22	3.8	2	0.3	127	21.7	190	32.5	118	20.2	126	21.5	585	100.0
Death					2	1.6	2	1.1	1	0.8			5	0.9

HFMD hand-foot-mouth disease, ADEM acute disseminated encephalomyelitis, ME meningoencephalitis
^aSymptoms such as fever, cold syndrome, abdominal pain, sore throat and manifestations of a suspected enterovirus infection

ISSN: 1471-2334