Skip to main content

Table 1 The Syrian hamster is more permissive to O. ochengi mf than BALB/c mice

From: Development and validation of an Onchocerca ochengi microfilarial hamster model for onchocerciasis drug screens

Animal Sex (M/F) Amount of O. ochengi mf injected Percentage viability of mf at time of injection Duration between mf injection and sacrifice (days) No of mf in fore limbs No of mf in hind limbs No of mf in ear lobes No of mf in tail No of mf in head No of mf in the trunk Total mf recovered (% recovered) % mf recovered in ear lobes relative to total recovery Tissue and whole body pathology
Hamster 1 M 12,558 100 % 21 7 7 60 0 7 0 81 (0.65) 74.07 None observed
Hamster 2 M 44,100 88 % 21 125 100 600 67 117 130 1039 (2.36) 57.75 None observed
Hamster 3 M 25,000 100 % 30 27 7 353 0 67 53 507 (2) 69.63 None observed
BALB/c 1 M 25,000 100 % 15 120 20 390 20 610 180 1340 (5.36) 29.10 None observed
BALB/c 2 M 25,000 100 % 30 0 0 0 0 0 0 0 (0) 0 None observed
BALB/c 3 M 25,000 100 % 31 0 0 0 0 0 0 0 (0) 0 None observed
BALB/c 4 M 25,000 100 % 30 0 0 0 0 0 0 0 (0) 0 None observed
BALB/c 5 F 25,000 100 % 31 0 0 0 0 0 0 0 (0) 0 None observed
  1. Different numbers of O. ochengi mf isolated from cattle skin on different days were injected subcutaneously at the nape of different animal types and the animals were sacrificed on indicated days and analyzed for O. ochengi mf (n = 3–5/group)