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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

Fig. 1

Ex vivo MGIA comparing growth inhibition conferred by BCG SSI and BCG Pasteur Aeras. a 1 × 106 splenocytes or 2 × 106 splenocytes from mice immunized with BCG SSI (grey circles) or given saline (open squares) were co-cultured with 3800, 675, or 90 CFU of BCG SSI. b 1 × 106 splenocytes from mice immunized with BCG Pasteur Aeras (grey circles) or given saline (open squares) were co-cultured with 2000, 500, or 100 CFU of BCG Pasteur Aeras. Splenocytes were obtained from a total of 5 immunized and 5 control animals (a) or a total of 6 immunized and 6 control animals (b). Aliquots from each spleen were cultured with different numbers of mycobacteria as indicated, and are represented by individual data points. Error bars represent the median +/- interquartile range. Statistical significance was tested using the unpaired t test function in GraphPad Prism

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