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Table 1 Glycosylation sites in the hemagglutinin (HA) of H3N2 viruses isolated from clinical specimens

From: Re-emergence of H3N2 strains carrying potential neutralizing mutations at the N-linked glycosylation site at the hemagglutinin head, post the 2009 H1N1 pandemic

Virus Donor Glycosylation sites in HA
Age Sex 45 63 122 126 133 144 165 246
2010–11 season
 A/Okayama/2/11 (Oka/2) 4 F SSS NCT NES NWT NGT KNS NVT NST
 A/Okayama/3/11 5 M SSS NCT NES NWT NGT NNS NVT NST
 A/Okayama/4/11 6 M SSS NCT NES NWT NGT KNS NVT NST
 A/Okayama/5/11 12 F SSS NCT NES NWT NGT KNS NVT NST
2011–12 season
 A/Shizuoka/10/12 4 M NSS NCT NES NWT NGT NNS NVT NST
 A/Shizuoka/23/12 (Sk/23) 2 F SPS NCT NES NWT NGT NNS NVT NST
 A/Shizuoka/24/12 5 M NSS NCT NES NWT NGT NNS NVT NST
 A/Shizuoka/26/12 (Sk/26) 5 M NSS NCT NES NWT NGT NNS NVT NST
  1. Residue 45 is located in the stem of HA, and residues 63, 122, 126, 133, 144, 165, and 246 are located in the globular head of HA
  2. Oka/2, Sk/23, and Sk/26 were used as representative 144K, 144N, and 45N/144N type viruses, respectively, to obtain neutralizing antibodies
  3. All samples were obtained from patients who had not received any medication prior to sample collection. Four samples (A/Okayama/2/11, A/Okayama/3/11, A/Okayama/4/11, and A/Okayama/5/11) were isolated in the Okayama prefecture in the 2010–11 season and four samples (A/Shizuoka/10/12, A/Shizuoka/23/12, A/Shizuoka/24/12, and A/Shizuoka/26/12) were isolated in the Shizuoka prefecture in the 2011–12 season