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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Associations between systemic inflammation, mycobacterial loads in sputum and radiological improvement after treatment initiation in pulmonary TB patients from Brazil: a prospective cohort study

Fig. 1

Prospective immune profiling of pulmonary TB patients before and 60 days after anti-mycobacterial treatment initiation. a Levels of C-reactive protein (CRP), indicated cytokines and erythrocyte sedimentation rate (ESR) were measured in serum samples from 73 patients with pulmonary TB at day 0 and 60 of anti-tuberculous treatment (ATT). Data were analyzed using Wilcoxon matched pairs test. Dotted lines represent median values detected in age- and gender-matched uninfected and healthy controls (n = 10), to serve as reference. b Network analysis was performed based on Spearman correlation matrices as described in Methods. Each connecting line represents a statistically significant correlation (p < 0.05). The strength (r value) and level of significance (p-value) for each significant correlation is shown in Additional file 1: Table S1. c A model of principal component analysis (PCA) was employed to test whether combination of the markers could cluster the patients at different time points of ATT (left panel). Vector analysis was further utilized to illustrate the influence of each marker in data distribution of the PCA model (center panel). Delta variation of the indicated markers from day 0 to day 60 of ATT initiation (right panel). Data represent median and interquartile ranges. d A second model of PCA in which all variable were included except from those with the largest delta variation from day 0 to day 60 of ATT was designed. HC = healthy controls, PC = principal component

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