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Table 2 Characteristics and Cardiovascular Risk Profile of INI Cohort Participants Exposed to ART from 2000–2010

From: Traditional and HIV-specific risk factors for cardiovascular morbidity and mortality among HIV-infected adults in Brazil: a retrospective cohort study

     CVD Events VTE events
   All study participants No CVD-related events Composite CVD events† CVD-related hospitalization CVD-related death VTE hospitalizations
and death
   n n (%) n (%) n (%) n (%) N (%)
Demographic & clinical characteristics 2,960 2,851 (96 %) 109 (4 %) 89 (3 %) 33 (1 %) 30 (1 %)
Median Age at study start (IQR) 37 (30, 43) 36 (30, 43) 42 (35, 51)* 40 (35, 50)* 46 (37, 58)* 36.5 (31, 44)
Age <30 years 710 (24 %) 692 (24 %) 18 (17 %) 14 (16 %) 5 (15 %) 7 (23 %)
  30–39 years 1,107 (37 %) 1,080 (38 %) 27 (25 %) 25 (28 %) 6 (18 %)** 11 (37 %)
  ≥40 years 1,143 (39 %) 1,079 (25 %) 64 (59 %) 50 (56 %) 22 (67 %) 12 (40 %)
Male Gender 1,924 (65 %) 1,849 (65 %) 75 (69 %) 64 (72 %) 21 (64 %) 23 (77 %)
White Race 1,605 (54 %) 1,554 (55 %) 51 (47 %) 40 (45 %) 15 (45 %) 12 (40 %)
≤8 years of Education 1,556 (53 %) 1,487 (52 %) 69 (64 %)** 57 (64 %)** 24 (73 %)** 16 (53 %)
History of IDU 61 (2 %) 58 (2 %) 3 (3 %) 3 (3 %) 1 (3 %) 0 (0 %)
History of Cocaine Use 262 (9 %) 255 (9 %) 7 (6 %) 6 (7 %) 1 (3 %) 2 (7 %)
Time since HIV diagnosis, Median years (IQR) 1.12 (0.13, 5.78) 1.08 (0.13, 5.7) 3.06 (0.24, 6.72)* 3.06 (0.29, 6.5)* 4.7 (0.24, 7.56) 1.35 (0.13, 3.22)
% of time on ART since HIV diagnosis 0.77 (0.47, 0.93) 0.77 (0.47, 0.93) 0.72 (0.43, 0.89) 0.71 (0.42, 0.89) 0.87 (0.52, 0.98) 0.67 (0.41, 0.93)
Median Nadir CD4+ T-cell count, cells/mm3 (IQR) 149 (52, 258) 152 (53, 259) 97 (27, 189)* 88.5 (23, 203)* 104.5 (23.5, 188.5)* 91 (27.5, 182.5)*
Nadir CD4+ T-cell count ≤ 50 cecells/mm3 705 (24 %) 666 (23 %) 39 (36 %)** 33 (37 %)** 13 (39 %)** 11 (37 %)
Virally suppressed year before event 1,771 (60 %) 1,734 (61 %) 37 (34 %)** 29 (33 %)** 14 (42 %)** 9 (30 %)**
Median viremia copy-years, log10 copy x years/mL (IQR) 4.72 (3.99, 5.34) 4.71 (3.98, 5.34) 4.94 (4.33, 5.67) 4.93 (4.28, 5.66)* 4.43 (3.76, 5.06) 5.08 (4.73, 5.82)*
Cardiovascular risk factors
History of Diabetes Mellitus 320 (11 %) 299 (10 %) 21 (19 %)** 18 (20 %)** 5 (15 %) 5 (17 %)
History of Hypertension 792 (27 %) 740 (26 %) 52 (48 %)** 42 (47 %)** 19 (58 %)** 9 (30 %)
History of Dyslipidemiaa 1,487 (50 %) 1,429 (50 %) 58 (53 %) 44 (49 %) 21 (64 %) 11 (37 %)
History of Chronic kidney disease 25 (<1 %) 23 (<1 %) 2 (2 %) 2 (2 %) 1 (3 %) 0 (0 %)
>1 metabolic risk factors for CVD 1,813 (61 %) 1,734 (61 %) 79 (72 %)** 62 (70 %) 29 (88 %)** 17 (57 %)
Prior CVDb 97 (3 %) 81 (3 %) 16 (15 %)** 9 (10 %)** 11 (33 %)** 2 (7 %)
Ever smoked 2,013 (68 %) 1,926 (68 %) 87 (80 %)** 67 (75 %) 33 (100 %)** 21 (70 %)
Median weight kg (IQR)~ 71.3 (62.5, 81.3) 71.6 (62.8, 81.4) 67.6 (60.5, 78.5) 67.5 (60.1, 78.5) 68.6 (60.3, 88) 68.8 (61, 79.2)
  1. Abbreviations: IQR interquartile range, CVD cardiovascular disease
  2. †Composite CVD events include all CVD-related hospitalizations and deaths listed in Table 1
  3. *Rank sum test of comparison of event and non-event groups p < 0.05
  4. **Chi square test of comparison of event and non-event groups p < 0.05
  5. ~based on the highest weight recorded prior to the end of follow-up or time of event
  6. aincludes any lab confirmed history of dyslipidemia, hypercholesterolemia, or hypertriglyceridemia, and patients on lipid-lowering drugs
  7. bPrior CVD = history of MI, CAD, or stroke