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Table 2 Characteristics and Cardiovascular Risk Profile of INI Cohort Participants Exposed to ART from 2000–2010

From: Traditional and HIV-specific risk factors for cardiovascular morbidity and mortality among HIV-infected adults in Brazil: a retrospective cohort study

    

CVD Events

VTE events

  

All study participants

No CVD-related events

Composite CVD events†

CVD-related hospitalization

CVD-related death

VTE hospitalizations

and death

  

n

n (%)

n (%)

n (%)

n (%)

N (%)

Demographic & clinical characteristics

2,960

2,851 (96 %)

109 (4 %)

89 (3 %)

33 (1 %)

30 (1 %)

Median Age at study start (IQR)

37 (30, 43)

36 (30, 43)

42 (35, 51)*

40 (35, 50)*

46 (37, 58)*

36.5 (31, 44)

Age

<30 years

710 (24 %)

692 (24 %)

18 (17 %)

14 (16 %)

5 (15 %)

7 (23 %)

 

30–39 years

1,107 (37 %)

1,080 (38 %)

27 (25 %)

25 (28 %)

6 (18 %)**

11 (37 %)

 

≥40 years

1,143 (39 %)

1,079 (25 %)

64 (59 %)

50 (56 %)

22 (67 %)

12 (40 %)

Male Gender

1,924 (65 %)

1,849 (65 %)

75 (69 %)

64 (72 %)

21 (64 %)

23 (77 %)

White Race

1,605 (54 %)

1,554 (55 %)

51 (47 %)

40 (45 %)

15 (45 %)

12 (40 %)

≤8 years of Education

1,556 (53 %)

1,487 (52 %)

69 (64 %)**

57 (64 %)**

24 (73 %)**

16 (53 %)

History of IDU

61 (2 %)

58 (2 %)

3 (3 %)

3 (3 %)

1 (3 %)

0 (0 %)

History of Cocaine Use

262 (9 %)

255 (9 %)

7 (6 %)

6 (7 %)

1 (3 %)

2 (7 %)

Time since HIV diagnosis, Median years (IQR)

1.12 (0.13, 5.78)

1.08 (0.13, 5.7)

3.06 (0.24, 6.72)*

3.06 (0.29, 6.5)*

4.7 (0.24, 7.56)

1.35 (0.13, 3.22)

% of time on ART since HIV diagnosis

0.77 (0.47, 0.93)

0.77 (0.47, 0.93)

0.72 (0.43, 0.89)

0.71 (0.42, 0.89)

0.87 (0.52, 0.98)

0.67 (0.41, 0.93)

Median Nadir CD4+ T-cell count, cells/mm3 (IQR)

149 (52, 258)

152 (53, 259)

97 (27, 189)*

88.5 (23, 203)*

104.5 (23.5, 188.5)*

91 (27.5, 182.5)*

Nadir CD4+ T-cell count ≤ 50 cecells/mm3

705 (24 %)

666 (23 %)

39 (36 %)**

33 (37 %)**

13 (39 %)**

11 (37 %)

Virally suppressed year before event

1,771 (60 %)

1,734 (61 %)

37 (34 %)**

29 (33 %)**

14 (42 %)**

9 (30 %)**

Median viremia copy-years, log10 copy x years/mL (IQR)

4.72 (3.99, 5.34)

4.71 (3.98, 5.34)

4.94 (4.33, 5.67)

4.93 (4.28, 5.66)*

4.43 (3.76, 5.06)

5.08 (4.73, 5.82)*

Cardiovascular risk factors

History of Diabetes Mellitus

320 (11 %)

299 (10 %)

21 (19 %)**

18 (20 %)**

5 (15 %)

5 (17 %)

History of Hypertension

792 (27 %)

740 (26 %)

52 (48 %)**

42 (47 %)**

19 (58 %)**

9 (30 %)

History of Dyslipidemiaa

1,487 (50 %)

1,429 (50 %)

58 (53 %)

44 (49 %)

21 (64 %)

11 (37 %)

History of Chronic kidney disease

25 (<1 %)

23 (<1 %)

2 (2 %)

2 (2 %)

1 (3 %)

0 (0 %)

>1 metabolic risk factors for CVD

1,813 (61 %)

1,734 (61 %)

79 (72 %)**

62 (70 %)

29 (88 %)**

17 (57 %)

Prior CVDb

97 (3 %)

81 (3 %)

16 (15 %)**

9 (10 %)**

11 (33 %)**

2 (7 %)

Ever smoked

2,013 (68 %)

1,926 (68 %)

87 (80 %)**

67 (75 %)

33 (100 %)**

21 (70 %)

Median weight kg (IQR)~

71.3 (62.5, 81.3)

71.6 (62.8, 81.4)

67.6 (60.5, 78.5)

67.5 (60.1, 78.5)

68.6 (60.3, 88)

68.8 (61, 79.2)

  1. Abbreviations: IQR interquartile range, CVD cardiovascular disease
  2. †Composite CVD events include all CVD-related hospitalizations and deaths listed in Table 1
  3. *Rank sum test of comparison of event and non-event groups p < 0.05
  4. **Chi square test of comparison of event and non-event groups p < 0.05
  5. ~based on the highest weight recorded prior to the end of follow-up or time of event
  6. aincludes any lab confirmed history of dyslipidemia, hypercholesterolemia, or hypertriglyceridemia, and patients on lipid-lowering drugs
  7. bPrior CVD = history of MI, CAD, or stroke