Table 2 Positive blood cultures and SeptiFast results, physicians’ judgement, clinical findings and the resulting changes in antimicrobial therapy
BC | SeptiFast | Judgement | Significant clinical information | Lab findings | Other specimen | Change of therapy | |
|---|---|---|---|---|---|---|---|
1 | Stenotrophomonas maltophilia, Streptococcus pneumoniae | Infection with stenotro-phomonas | Neuropediatric, PICU, MV, VP | PCT 32.13 ng/ml CRP 6.8 mg/dl WBC 3.43/nl | Throat swab: Streptococcus pneumoniae (colonisation) | SF: Additionally cotrimoxazole | |
2 | Pseudomonas aeruginosa | Infection | After liver tx | PCT 1.87 ng/ml CRP 14.1 mg/dl WBC 1.05/nl | No (under therapy with piperacillin/ tazobactam, fosfomycin) | ||
3 | Enterobacter cloacae | Infection | BPD, PICU, MV, VP, 38.7 °C | PCT not done CRP 2.3 mg/dl WBC 3.43/nl | Tracheal aspirate: Enterobacter cloacae | No (under cefotaxime) | |
9 | CONS | Enterobacter cloacae | Co-infection | Neuropediatric, PICU, MV, 40.5 °C | PCT 0.53 ng/ml CRP 0.5 mg/dl WBC 24.13/nl | SF: Meropenem instead of cefotaxime BC: Additionally vancomycin | |
13 | Pseudomonas aeruginosa | Not assessable | ALL relapse, 38.8 °C | PCT not done CRP 11.3 mg/dl WBC 0.19/nl | No | ||
15 | Klebsiella pneumoniae | Infection | After bone marrow tx, 38.6 °C | PCT not done CRP 19.5 mg/dl WBC 10.2/nl | SF: Additionally ciprofloxacin | ||
18 | CONS | CONS, Candida albicans | Co-infection | Neuropediatric, PICU, 39.4 °C | PCT 0.59 ng/ml CRP 2 mg/dl WBC 7.8/nl | Second BC: CONS | SF: Additionally fluconazole |
19 | Klebsiella pneumoniae | Infection | After liver tx, PICU, MV, VP, 34 °C | PCT 8.04 ng/ml CRP 8.5 mg/dl WBC 14.62/nl | No (under Piperacillin/tazobactam) | ||
20 | Escherichia coli | Infection | After liver tx, recurring cholangitis | PCT 1.21 ng/ml CRP 10.2 mg/dl WBC 15.05/nl | No (under ciprofloxacin) | ||
26 | Streptococcus spp. | Infection | ALL, PICU, MV, 38.8 °C | PCT 22.52 ng/ml CRP 39.8 mg/dl WBC 0.04/nl | BC 2 days before study: Streptococcus spp. | No (under meropenem) | |
32 | Candida albicans | Enterococcus faecalis, fungi PCR n/a | Co-infection | Non-Hodgkin-lymphoma, PICU, 38.6 °C | PCT 0.97 ng/ml CRP 6.6 mg/dl WBC 0.1/nl | BC: New CVC; additionally caspofungin, SF: linezolid instead of vancomycin | |
37 | Candida albicans | Infection | ALL, 39.2 °C | PCT 1.1 ng/ml CRP 18.8 mg/dl WBC 0.95/nl | Throat swab: Candida albicans (colonisation) | No (liposomal amphotericin B was started before SF result) | |
38 | Pseudomonas aeruginosa | Infection | After kidney tx, PICU, MV, VP | PCT 72.01 ng/ml CRP 6.4 mg/dl WBC 7.61/nl | Tracheal aspirate, ascites: Pseudomonas aeruginosa | SF: Meropenem instead of cefazoline | |
39 | Klebsiella pneumoniae | Klebsiella pneumoniae, Streptococcus spp. | Infection with Klebsiella | After liver tx, short bowel syndrome | PCT 14.56 ng/ml, CRP14 mg/dl WBC 1.56/nl | Bile: Klebsiella pneumoniae | BC+ SF: Discontinuation of vancomycin |