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Table 2 Main regression models in FemCure study

From: Design of the FemCure study: prospective multicentre study on the transmission of genital and extra-genital Chlamydia trachomatis infections in women receiving routine care

  Exposure categories Definition in the datab Interpretationc of positive CT test result
Outcome incident genital CT detection
Model 1 Sexual exposurea Genital sexual exposure (at Tx)  
  Alternate site exposure Anorectal CT positive (at Tx and/or Tx-2)  
Model 2 No exposure No genital sexual exposure (at Tx) AND anorectal CT negative (at Tx and Tx-2) Persistence
  Genital sexual exposure only Genital sexual exposure (at Tx) AND anorectal CT negative (at Tx and Tx-2) Sexual transmission
  Anorectal site exposure only No genital sexual exposure (at Tx) AND anorectal CT positive (at Tx and/or Tx-2) Transmission from anorectal site
  Sexual exposure and anorectal site exposure Genital sexual exposure (at Tx) AND anorectal CT positive (at Tx and/or Tx-2) Sexual transmission AND/OR Transmission from anorectal site
Outcome incident anorectal CT detection
Model 1 Sexual exposurea Anorectal sexual exposure (at Tx)  
  Alternate site exposure Genital CT positive (at Tx and/or Tx-2)  
Model 2 No exposure No anorectal sexual exposure (at Tx) AND genital CT negative (at Tx and Tx-2) Persistence
  Anorectal sexual exposure only Anorectal sexual exposure (at Tx) AND genital CT negative (at Tx and Tx-2) Sexual transmission
  Genital site exposure only No anorectal sexual exposure (at Tx) AND genital CT positive (at Tx and/or Tx-2) Transmission from genital site
  Sexual exposure and genital site exposure Anorectal sexual exposure (at Tx) AND genital CT positive (at Tx and/or Tx-2) Sexual transmission AND/OR Transmission from genital site
  1. aBased on self-administered questionnaires and semen biomarker assessment
  2. bTx: test result at the sampling; Tx-2: test result at the sampling two weeks earlier
  3. cStrain typing is used to further aid interpretation of the observed positive CT test result, specifically to confirm self-infection (i.e., strain types do not differ between anatomic sites) or persistence (i.e., strain types do not differ over time)