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Table 2 Main regression models in FemCure study

From: Design of the FemCure study: prospective multicentre study on the transmission of genital and extra-genital Chlamydia trachomatis infections in women receiving routine care

 

Exposure categories

Definition in the datab

Interpretationc of positive CT test result

Outcome incident genital CT detection

Model 1

Sexual exposurea

Genital sexual exposure (at Tx)

 
 

Alternate site exposure

Anorectal CT positive (at Tx and/or Tx-2)

 

Model 2

No exposure

No genital sexual exposure (at Tx) AND anorectal CT negative (at Tx and Tx-2)

Persistence

 

Genital sexual exposure only

Genital sexual exposure (at Tx) AND anorectal CT negative (at Tx and Tx-2)

Sexual transmission

 

Anorectal site exposure only

No genital sexual exposure (at Tx) AND anorectal CT positive (at Tx and/or Tx-2)

Transmission from anorectal site

 

Sexual exposure and anorectal site exposure

Genital sexual exposure (at Tx) AND anorectal CT positive (at Tx and/or Tx-2)

Sexual transmission AND/OR Transmission from anorectal site

Outcome incident anorectal CT detection

Model 1

Sexual exposurea

Anorectal sexual exposure (at Tx)

 
 

Alternate site exposure

Genital CT positive (at Tx and/or Tx-2)

 

Model 2

No exposure

No anorectal sexual exposure (at Tx) AND genital CT negative (at Tx and Tx-2)

Persistence

 

Anorectal sexual exposure only

Anorectal sexual exposure (at Tx) AND genital CT negative (at Tx and Tx-2)

Sexual transmission

 

Genital site exposure only

No anorectal sexual exposure (at Tx) AND genital CT positive (at Tx and/or Tx-2)

Transmission from genital site

 

Sexual exposure and genital site exposure

Anorectal sexual exposure (at Tx) AND genital CT positive (at Tx and/or Tx-2)

Sexual transmission AND/OR Transmission from genital site

  1. aBased on self-administered questionnaires and semen biomarker assessment
  2. bTx: test result at the sampling; Tx-2: test result at the sampling two weeks earlier
  3. cStrain typing is used to further aid interpretation of the observed positive CT test result, specifically to confirm self-infection (i.e., strain types do not differ between anatomic sites) or persistence (i.e., strain types do not differ over time)