Tigecycline-based versus sulbactam-based treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex

Table 3 Multivariate analyses of the predictors for mortality during treatment including combination therapy, carbapenems or colistin use, and polymicrobial pneumonia

Variables	Odds ratio	95 % confidence interval	p
Model A^a
With skin and soft tissue infection	2.041	0.644–6.466	0.225
MDR Acb complex with TG or SB resistance	0.418	0.160–1.092	0.075
Bilateral pneumonia	2.663	0.987–7.186	0.053
Tigecycline-based treatment	1.405	0.608–3.245	0.426
Combination therapy	1.133	0.472–2.720	0.779
Model B^b
With skin and soft tissue infection	2.071	0.657–6.523	0.214
MDR Acb complex with TG or SB resistance	0.426	0.163–1.114	0.082
Bilateral pneumonia	2.717	1.007–7.329	0.048
Tigecycline-based treatment	1.373	0.497–3.795	0.541
Combination with carbapenem	1.002	0.346–2.905	0.997
Model C^c
With skin and soft tissue infection	2.002	0.624–6.425	0.243
MDR Acb complex with TG or SB resistance	0.420	0.161–1.090	0.075
Bilateral pneumonia	2.795	1.028–7.600	0.044
Tigecycline-based treatment	1.430	0.608–3.363	0.413
Combination with colistin	0.783	0.178–3.444	0.746
Model D
With skin and soft tissue infection	2.035	0.639–6.485	0.230
MDR Acb complex with TG or SB resistance	0.428	0.165–1.111	0.081
Bilateral pneumonia	2.711	1.013–7.254	0.047
Tigecycline-based treatment	1.362	0.598–3.102	0.462
Polymicrobial pneumonia	1.109	0.426–2.884	0.833
Model E
With skin and soft tissue infection	1.979	0.612–6.405	0.254
MDR Acb complex with TG or SB resistance	0.422	0.160–1.110	0.080
Bilateral pneumonia	2.781	1.014–7.624	0.047
Tigecycline-based treatment	1.422	0.498–4.056	0.510
Polymicrobial pneumonia	1.086	0.413–2.853	0.868
Combination with colistin	0.797	0.179–3.557	0.767
Combination with carbapenem	1.006	0.346–2.921	0.991

Abbreviations: MDR Acb multidrug resistant Acinetobacter calcoaceticus-Acinetobacter baumannii, TG tigecycline, SB sulbactam
^aNo significant predictor was revealed when model A included polymicrobial pneumonia
^bBilateral pneumonia was the only significant predictor when model B included polymicrobial pneumonia (p = 0.049, adjusted odds ratio, 2.709; 95 % confidential interval, 1.004–7.305)
^cBilateral pneumonia was the only significant predictor when model C included polymicrobial pneumonia (p = 0.045, adjusted odds ratio, 2.783; 95 % confidential interval, 1.023–7.569)

ISSN: 1471-2334