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Table 2 Time to adequate antibiotic therapy and risk ratios for in-hospital mortality and unfavourable outcome at discharge among patients with community-acquired bacterial meningitis

From: Time to antibiotic therapy and outcome in bacterial meningitis: a Danish population-based cohort study

Adequate antibiotic therapy initiated

Risk ratio for in-hospital mortality (95 % CI)

Risk ratio for unfavourable outcome (95 % CI)

Crude

Adjusteda

Crude

Adjustedb

0–2 h after admission

Ref.

Ref.

Ref.

Ref.

2–4 h after admission

1.1 (0.5–2.8)

1.2 (0.5–2.7)

1.4 (0.9–2.2)

1.5 (0.9–2.2)

4–6 h after admission

1.4 (0.4–5.3)

1.4 (0.5–3.6)

1.1 (0.5–2.6)

1.1 (0.6–2.2)

>6 h after admission

2.1 (1.0–4.2)*

1.6 (0.8–3.2)

1.7 (1.2–2.5)*

1.5 (1.0–2.2)*

  1. *p < 0.05. CI indicates confidence interval. aAdjusted for age >65 years, Glasgow Coma Score <13 and arterial systolic hypotension (<90 mmHg) at admission. bAdjusted for age >65 years, Glasgow Coma Score <13, arterial systolic hypotension (<90 mmHg), bacterial aetiology (S. pneumoniae yes/no) and adjunctive dexamethasone treatment (yes/no)