Table 3 Unadjusted and adjusted association with dual therapy discontinuation by any cause (Cox proportional Hazard Model)
Unadjusted HR (95 % CI) | Adjusted HR (95 % CI) | P value | |
|---|---|---|---|
Male gender | 1.08 (0.63–1.86) | 1.12 (0.65–1.92) | n.s. |
Age (by year) | 1.09 (0.98–1.02) | 1.00 (0.97–1.03) | n.s. |
Non-Italian origin | 0.45 (0.17–1.24) | 0.43 (0.15–1.24) | n.s. |
Years on cART (each) | 0.97 (0.94–1.01) | 0.94 (0.89–1.00) | 0.033 |
IDU as risk factor | 1.02 (0.93–1.12) | 1.01 (0.91–1.11) | n.s. |
AIDS diagnosis | 1.19 (0.75–1.89) | 0.84 (0.49–1.44) | n.s. |
No. of previous regimens (per each one more) | 1.04 (1.00–1.09) | 1.10 (1.01–1.13) | 0.027 |
CD4 nadir (by 50) | 1.37 (0.84–2.21) | 1.43 (0.81–2.52) | n.s. |
<200 /mmc Baseline CD4 count | 2.07 (1.19–3.60) | 2.18 (1.18–4.03) | 0.013 |
HCV coinfection | 0.99 (0.61–1.60) | 1.26 (0.75–2.11) | n.s. |
Previous virological failure | 0.89 (0.55–1.42) | 1.14 (0.95–1.38) | n.s. |
Switch to (PI/r) | |||
ATV/r | 0.79 (0.41–1.49) | 0.29 (0.09–0.99) | 0.049 |
DRV/r | 0.61 (0.39–0.96) | 0.21 (0.07–0.63) | 0.005 |
LPV/r | 2.06 (1.25–3.42) | 0.46 (0.14–1.50) | n.s. |
Switch to (Second Drug) | |||
ETR | 1.41 (0.83–2.40) | 0.62 (0.23–1.68) | n.s. |
RAL | 0.67 (0.43–1.05) | 0.37 (0.13–1.04) | n.s. |
MVC | 0.74 (0.34–1.62) | 0.49 (0.15–1.62) | n.s. |
3TC | 1.66 (0.62–3.84) | 0.65 (0.18–2.39) | n.s. |
TDF | 1.39 (0.67–2.91) | 0.59 (0.18–1.93) | n.s. |